Equipment
Leistritz ZSE 12 HP-PH twin screw hot melt extruder for hot melt extrusion (HME) and twin screw granulation (TSG) with supporting equipment for material feed, cooling and processing of extrudates
The device is capable of continuous and controlled delivery of the powder mixture of materials into the device itself and the following continuous production of solid dispersions of the active ingredients in the polymeric matrix. On exit from the die the filaments are continuous cooled on the conveyor belt and then cut into pellets of defined lengths (from 1.0 to 2.0 mm). Conversion of the device enables the process of continuous wet granulation of powder materials with controlled addition of granulation fluid to control the ratio of liquid to solids in a continuous granulation process. The device has eight-zone temperature control of the processed material, where each zone is actively cooled and or heated, for the purpose of controlling the viscosity of the material mixture, or to maintain thermally conditioned stability of the processed materials (applies to the melt extrusion and granulation process).
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