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Projects / Programmes source: ARIS

Transplantation of human autologous chondrocytes cultivated in vitro

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Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B500  Biomedical sciences  Immunology, serology, transplantation 
B600  Biomedical sciences  Surgery, orthopaedics, traumatology 
Keywords
articular cartilage, chondrocytes, cell and tissue cultures, dedifferentiation, redifferentiation, autologous transplantation
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publications
1.  02745  PhD Mateja Bohinjec  Microbiology and immunology  Researcher  1998 - 1999  72 
2.  01302  PhD Matjaž Jeras  Biotechnology  Head  1997 - 1999  363 
3.  17490  Marjana Limoni    Researcher  1998 - 1999  0 
4.  12336  PhD Primož Rožman  Microbiology and immunology  Researcher  1997 - 1999  483 
5.  10453  PhD Blanka Vidan-Jeras  Microbiology and immunology  Researcher  1998 - 1999  136 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0311  Blood Transfusion Centre of Slovenia  Ljubljana  5053960  1,737 
Abstract
The main goal of the project is to introduce into routine clinical practice a novel therapeutic procedure for regeneration of injured articular cartilage by means of re-implantation of autologous chondrocytes, cultivated in vitro. The main research stream is oriented towards optimisation of cell and tissue culture conditions, assurance of a safe and effective chondrocyte suspension as well as surgical re-implantation. There are several tasks that are being pursuit in the fraim of the project: improvements of surgical techniques, especially attachment of periosteal flap over the injured part of the cartilage in the joint; search for the most effective serum-free cell culture medium; detecting and influencing de-differentiation and re-differentiation steps of chondrocytes in cell cultures; developement of most appropriate procedures for detection of typical protein macromelecules of articular cartilage - collagens of type II, IX and XI as well as aggrecan; study of physiology and metabolism of chondrocytes; getting an insight of the mechanisms of repopulation of cells and regeneration of cartilage at the site of the injury after re-implantation of chondrocytes, cultivated in vitro; study of immunogenicity of allogeneic chondrocytes and components of the cartilage matrix; histological studies of biopsies of regenerated cartilage; testing of different biocompatible and biodegradable matrices used for in vitro preparation of three-dimensional cartilage constructs; developement of procedures and techniques for the application of in vitro cultivated chondrocytes also in other fields of medicine - ORL, reparative and thoracic surgery and urology.
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