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International projects source: SICRIS

GLISTEN: GPCR-Ligand Interactions, Structures, and Transmembrane Signalling: a European Research Network

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Researchers (2)
no. Code Name and surname Research area Role Period No. of publications
1.  20214  PhD Nina Vardjan  Neurobiology  Researcher  2013 - 2017  267 
2.  13334  PhD Milka Vrecl Fazarinc  Veterinarian medicine  Researcher  2013 - 2017  269 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,756 
Abstract
G protein-coupled receptors (GPCRs) are the largest family of proteins involved in signal transduction across membranes and one of the most important pharmaceutical drug target classes. In the past five years, an unprecedented number of X-ray structures of GPCRs have been solved, affording us first peeks at the molecular details of their function. Based on these and forthcoming structures, this COST Action will bring together experts in a wide range of complementary methods to unravel details of the activation mechanism, ligand binding, and the effect of the membrane and other interaction partners on GPCRs. The information exchange that will be made possible by the COST Action will lead to innovative insights into mechanistic details of GPCR function. This will in turn give rise to novel effector molecules to be used as lead structures for drug development, offering valuable new opportunities for European pharmaceutical research and industry.
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