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Projects / Programmes source: ARIS

Racionalna diagnostika in zdravljenje tumorjev ščitnice (Slovene)

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B200  Biomedical sciences  Cytology, oncology, cancerology 
Keywords
follicular, anaplastic thyroid carcinoma, thyroglobulin, Velbe, Adria, cell membrane fluidity, DNA flow cytometry, cytomorphology
Evaluation (rules)
source: COBISS
Researchers (17)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  00705  PhD Marija Auersperg  Oncology  Researcher  1996 - 2001  203 
2.  08748  MSc Damijan Bergant  Oncology  Researcher  2000 - 2001  90 
3.  10330  PhD Nikola Bešić  Oncology  Head  1999 - 2001  468 
4.  02636  PhD Marija Bizjak-Schwarzbartl  Oncology  Researcher  1996 - 2001  19 
5.  02686  PhD Rastko Golouh  Oncology  Researcher  1996 - 2001  364 
6.  09170  Janez Jančar  Oncology  Researcher  1999 - 2001  84 
7.  04377  Tadeja Movrin-Stanovnik  Oncology  Researcher  1996 - 2001  31 
8.  08754  Gabrijela Petrič-Grabnar  Oncology  Researcher  2000 - 2001  66 
9.  04401  PhD Ana Pogačnik  Oncology  Researcher  2000 - 2001  168 
10.  12199  PhD Živa Pohar Marinšek  Oncology  Researcher  1999 - 2001  143 
11.  12230  Franc Pompe  Oncology  Researcher  1999 - 2001  44 
12.  05342  MSc Ljudmila Ruparčič-Oblak  Oncology  Researcher  1996 - 2001 
13.  09216  Mojca Senčar  Oncology  Researcher  1999 - 2001  71 
14.  08800  PhD Gregor Serša  Oncology  Researcher  2000 - 2001  1,516 
15.  15829  MSc Radka Tomšič-Demšar  Oncology  Researcher  1996 - 2001  32 
16.  12198  Alenka Vodnik-Cerar  Oncology  Researcher  1999 - 2001  27 
17.  02747  Andreja Zidar  Oncology  Researcher  1998 - 2001  40 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,495 
Abstract
Well differentiated follicular thyroid tumors are a diagnostic, whereas anaplastic tumors are a therapeutic problem. The value of preoperative determination of thyroglobulin (Tg) in the serum for differential diagnosis of follicular tumors was evaluated in 516 patients. The Tg values were significantly higher in follicullar and Huerthle cell carcinomas then in other histologic entities including adenomas. A multivariate analysis of various factors in 154 patients with follicular carcinomas showed that tumor differentiation, primary tumor size, vascular invasion, distant or regional metastases, histological tumor type and age are independent prognostic factors connected with survival. In 9 patients with inoperablle or disseminated carcinomas the effect of low doses of vinblastine (Velbe) or adriamycine (Adria) were studied by DNA measurements and monitorig of morphological changes of tumor cells in fine needle aspiration biopsy samples of tumors. The results of these measurements were used for planning of combination of Velbe or Adria with radiation or chemotherapy with a sequence of Velbe infusions. The influence of Velbe on cell membrane fluidity was studied by electrone paramagnetic resonance (EPR) on cell cultures of Velbe sensitive and Velbe resistant cells. Velbe increased cell membrane fluidity of sensitive cells already at subtoxic levels whereas there was no effect on the cell membrane fluidity of resistant cells.
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