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Projects / Programmes source: ARIS

Uravnavanje funkcije celičnih membran - vloga pri degeneraciji, regeneraciji in reparaciji (Slovene)

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B470  Biomedical sciences  Physiology 
B725  Biomedical sciences  Diagnostics 
Keywords
Degeneration, regeneration, reparation, MRI, EPR, confocal microscopy, eco-toxins, nervous system, endothelium, AChE, cardiotoxicity
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15667  PhD Matjaž Bunc  Neurobiology  Researcher  1998 - 2001  531 
2.  10779  PhD Rok Černe  Neurobiology  Researcher  1998 - 2001  39 
3.  05921  Dušanka Čuček  Neurobiology  Researcher  1998 - 2001 
4.  14542  PhD Irena Horvat-Žnidaršič  Neurobiology  Researcher  1996 - 2001  15 
5.  18549  PhD Aleksandra Milutinović Živin  Cardiovascular system  Researcher  1996 - 2001  127 
6.  07087  PhD Aleksander Rotter  Neurobiology  Researcher  1999 - 2001  50 
7.  09861  Jerneja Strupi-Šuput  Civil engineering  Researcher  1996 - 2001  134 
8.  07002  PhD Dušan Šuput  Neurobiology  Head  1998 - 2001  436 
9.  07088  PhD Boris Vodopivec  Neurobiology  Researcher  1998 - 2001  36 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,756 
Abstract
The project deals with the processes of degeneration of neuromuscular system, cardiovascular system, and parenhymatous organs. In 1998 the main topics were the study of neuro-degeneration and the role of exogenous proteins and other substances affecting this process, the study of cardiotoxicity of actinoporins, and the study of degeneration of parenhymatous organs due to action of ecotoxins. The methodological approach was based on the use of electrophysiology, MRI/MRS, EPR, laser confocal microscopy and microspectrofluorimetry. The study of the effects of actinoporins gave an insight into the membrane processes in the node of Ranvier, and also the mechanisms of regulation of cell volume and intracellular calcium homeostasis. The study of neurotoxic effects of L-ammodytin isolated from Vipera ammod. results has shown that L-ammodytin is a potent miotoxin with presynaptic actions, as well. Investigation of the effects of an alkylpyridinium salt isolated from marine sponge Reniera sarai revealed that this substance is a potent AChE inhibitor. Investigation of cardiovascular effects of actinoporins revealed an important role of vasoconstriction in the cardiotoxic action of those substances, and the results allow the conclusion that release of endothelins due to the action of actinoporins is the probable mechanism of vasoconstrictory action. The MRI study of liver regeneration after a major surgical resection showed that the initial rapid increase of the mass of the regenerating liver tissue is associated with an increased water content of the regenerated tissue. Results of the MRI study of liver degeneration due to the acute and chronic exposure to microcystins has provided a non-invasive tool for monitoring of the acute toxicity and of carcinogenic effects of those substances.
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