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Projects / Programmes source: ARIS

Farmakološka študija mehanizmov delovanja nevrotrofičnih dejavnikov, citokinov in nevrotransmiterjev (Slovene)

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B740  Biomedical sciences  Pharmacological sciences, pharmacognosy, pharmacy, toxicology 
Keywords
histamine, NGF, cytokines, cortical neurons, astrocytes, receptors
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (15)
no. Code Name and surname Research area Role Period No. of publications
1.  17934  Cvetka Blažek    Researcher  1998 - 2001  0 
2.  16341  MSc Orjeta Bonaca  Microbiology and immunology  Researcher  1996 - 2001  16 
3.  01169  PhD Marija Čarman-Kržan  Neurobiology  Head  1998 - 2001  170 
4.  08313  PhD Ilonka Ferjan  Neurobiology  Researcher  1998 - 2001  74 
5.  17937  Matjaž Hrovat    Researcher  1998 - 2001  0 
6.  15169  PhD Damijana Mojca Jurič  Neurobiology  Researcher  1996 - 2001  103 
7.  17935  Jožica Košir    Researcher  1998 - 2001  0 
8.  08095  PhD Mojca Kržan  Neurobiology  Researcher  1998 - 2001  271 
9.  15536  PhD Metoda Lipnik Štangelj  Neurobiology  Researcher  1998 - 2001  207 
10.  17933  Tatjana Lovšin    Researcher  1998 - 2001  0 
11.  12844  MSc Vesna Pahor  Pharmacy  Researcher  1998 - 2001  23 
12.  17932  Sonja Rozman    Researcher  1998 - 2001  0 
13.  17941  Vesna Vidergar Ivanić    Researcher  1998 - 2001  0 
14.  17942  Katja Vodopivec Mohorčič    Researcher  1998 - 2001  1 
15.  17944  Frančiška Zupan    Researcher  1998 - 2001  0 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,203 
Abstract
Molecular mechanisms involved in the stimulation of NGF secretion by cytokins (IL-1beta, IL-4, IL-6) and neurotransmitters (histamine) were studied on the model system of neonatal rat cortical astrocytes and cortical neurons in primary culture. In the astrocytes IL-1beta and histamine are potent stimulators of NGF secretion. Stimulation is mediated by IL-1beta and histamine H1-receptors, respectively. Cortical neurons do not respond to the stimulation by above substances. We identified and characterised specific histamine H1- and H2-receptor binding sites on our model system of astrocytes and compared their molecular properties with the H1- and H2-receptors identified in vascular system. For their characterisation we used new H1- selective agonists (derivatives of 2-phenylhistamine and histaprodifen). On the model system of isolated rat peritoneal mast cells two groups of drugs (tricyclic antidepresants and non-steroidal anti-inflammatory drugs (NSAIDs)) were studied for their ability to stimulate or inhibit histamine and serotonin release.
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