Genetska analiza nekaterih tumor supresor genov (Slovene)

Code

J3-7919 (C) - included in ARIS records

Head

PhD Metka Ravnik-Glavač

Period

1/1/1996 - 6/30/2001

Science

Natural sciences and mathematics (2)
Medical sciences (5)
Other (2)

Reseacher status

Researcher (9)
Junior expert or technical associate (0)

Education

Doctor's degree (6)
Other (3)

Sex

Woman (3)
Man (6)

Status

Employed at RO (1)
Employed at RO and RRD (2)
No data on employment in RO (2)
Retired (4)

No. of publications

0 (1)
1–9 (1)
10–99 (1)
100–999 (6)

Projects / Programmes source: ARIS

source: ARIS

Genetska analiza nekaterih tumor supresor genov (Slovene)

Research activity

Code	Science	Field	Subfield
3.04.00	Medical sciences	Oncology

Code	Science	Field
B007	Biomedical sciences	Medicine (human and vertebrates)
B200	Biomedical sciences	Cytology, oncology, cancerology

Keywords

tumor suppressor genes, oncogenes, genetic analysis, hereditary cancer, hereditary colorectal cancer, HNPCC, FAP, von Hippel-Lindau syndrome, multiple endocrine neoplasya, MEN 2, MEN 1, cancerogenesis, Slovenian population

Evaluation (rules)

source: COBISS

Evaluation of bibliographic research performance indicators according to ARIS methodology

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (9)

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	09275	PhD Damjan Glavač	Chemistry	Researcher	1998 - 2001	565
2.	02686	PhD Rastko Golouh	Oncology	Researcher	1998 - 2001	364
3.	13549	Matjaž Koželj	Metabolic and hormonal disorders	Researcher	1998 - 2001	106
4.	18361	Tomaž Krašovec		Researcher	1998 - 2001	5
5.	01546	PhD Igor Križman	Medical sciences	Researcher	1998 - 2001	144
6.	07187	PhD Andrej Mašera	Oncology	Researcher	1998 - 2001	132
7.	07228	PhD Zdenka Ovčak	Oncology	Researcher	1998 - 2001	78
8.	01502	PhD Metka Ravnik-Glavač	Biochemistry and molecular biology	Head	1998 - 2001	268
9.	18539	Veronika Špacapan		Researcher	1996 - 2001	0

Organisations (3)

no.	Code	Research organisation	City	Registration number	No. of publicationsNo. of publications
1.	0381	University of Ljubljana, Faculty of Medicine	Ljubljana	1627066	48,238
2.	0302	Institute of Oncology Ljubljana	Ljubljana	5055733000	15,468
3.	0312	University Medical Centre Ljubljana	Ljubljana	5057272000	77,465

Abstract

Genes most frequently connected with hereditary predisposition for cancer are tumor suppressor genes. Known genes (MSH2, MLH1, APC, PT53, VHL, RET) connected with hereditary colorectal cancer, von Hippel-Lindau syndrome, multiple endocrine neoplasya have been studied in Slovenian population. In addition mapping of possible new genes connected with defined pathology is under consideration. PCR-Conformational analysis, detection of LOH and linkage analysis have been used. Results of genetic study will represent a basis for population analysis and a contribution to understanding genetic mechanisms of cancer. The detection of mutation in a given family with hereditary cancer syndrome means also the possibility for presymptomatic genetic testing of family members at risk and thus early detection and prevention of the disease.