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Projects / Programmes source: ARIS

Fiziološki mehanizmi nevroloških bolezni (Slovene)

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
B560  Biomedical sciences  Urology, nephrology 
Keywords
Single fibre electromyography, axonal microstimulation, neuromuscular transmission, safety factor, neuromuscular junction disorders, uroneurophysiology, uroneurology, sacral nervous system, bulbocavernosus reflex, anal sphincter, electromyography, pudendal SEP, enuresis, transcranial stimulation, motor cortex, corticobulbar tract jitter, single motor unit, Charcot-Marie-Tooth disease type 1, CMT1A duplication, hereditary neuropathy with liability to pressure palsies, HNPP deletion, Thr118Met PMP22 amino acid substitution
Evaluation (rules)
source: COBISS
Researchers (38)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  04409  PhD Jelka Brecelj  Neurobiology  Researcher  1996 - 2001  347 
2.  06868  PhD Dušan Butinar  Neurobiology  Researcher  1996 - 2001  124 
3.  15400  PhD Leja Dolenc Grošelj  Neurobiology  Researcher  1996 - 2001  526 
4.  17658  Magdalena Dremelj    Researcher  1996 - 2001 
5.  17659  Marta Faganel    Researcher  1998 - 2001 
6.  17661  Marija Gospodarič    Researcher  1996 - 2001 
7.  11684  Milan Grgič  Neurobiology  Researcher  1996 - 2001  13 
8.  19652  Mojca Jager    Researcher  1996 - 2001 
9.  05270  PhD Martin Janko  Neurobiology  Researcher  1999 - 2001  110 
10.  17660  Tatjana Janko  Neurobiology  Researcher  1998 - 2001 
11.  17662  Cvija Jovanović    Researcher  1998 - 2001 
12.  17663  Suzana Justin Srebernjak    Researcher  1996 - 2001 
13.  17664  Barbara Koblar    Researcher  1996 - 2001 
14.  17665  Miloš Kogej    Researcher  1996 - 2001 
15.  17666  Lidija Kolnik    Researcher  2000 - 2001  13 
16.  17667  Blaž Konec    Researcher  1996 - 2001 
17.  17668  Zdenka Korelc    Researcher  1996 - 2001 
18.  17669  Silva Lenič    Researcher  1996 - 2001 
19.  15121  PhD Lea Leonardis  Neurobiology  Researcher  1996 - 2001  211 
20.  01947  PhD Marjan Mihelin  Neurobiology  Researcher  1996 - 2001  68 
21.  17671  Lidija Ocepek    Researcher  1996 - 2001  53 
22.  05380  PhD Zvezdan Pirtošek  Neurobiology  Researcher  1996 - 2001  751 
23.  14502  PhD Simon Podnar  Neurobiology  Researcher  1996 - 2001  402 
24.  01540  PhD Tine S. Prevec  Neurobiology  Researcher  1996 - 2001  116 
25.  17672  Stanislava Ristič Kovačič  Neurobiology  Researcher  1996 - 2001  32 
26.  12149  PhD Zoran Rodi  Neurobiology  Researcher  1996 - 2001  105 
27.  17673  Vanja Škedelj    Researcher  1996 - 2001 
28.  17674  Irena Štefe    Researcher  1998 - 2001 
29.  17670  Tanja Trdič    Researcher  1998 - 2001 
30.  00341  PhD Jože Trontelj  Neurobiology  Head  1996 - 2001  516 
31.  17675  Tatjana Vidmar    Researcher  1996 - 2001 
32.  17676  Vedrana Vlahovič    Researcher  1996 - 2001 
33.  07476  PhD David Božidar Vodušek  Neurobiology  Researcher  1996 - 2001  470 
34.  11736  Ignac Zidar  Neurobiology  Researcher  1996 - 2001  37 
35.  08780  PhD Janez Zidar  Neurobiology  Researcher  1996 - 2001  407 
36.  17677  Nevenka Zlatnar    Researcher  1996 - 2001 
37.  17678  Anton Žakelj    Researcher  1998 - 2001  30 
38.  07032  PhD Tomaž Žgur  Neurobiology  Researcher  1996 - 2001  53 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,903 
Abstract
In the first part of the project, microelectrophysiology of muscle with stimulation single fibre EMG, we investigated the effect of neural activity upon the level of mRNA for acetylcholinesterase. Aboundant fibrillation in the regenerating muscle maintained this level at 80% of the control value. Single fibre EMG was used for semiquantitative estimation of spontaneous activity in denervated muscle fibres and in the fibrillating myotubes. A method for diagnostic assessment of the neuromuscular jitter in the frontalis muscle was developed. The relationship between the jitter at individual neuromuscular junctions and their safety factor was studied. In the second part of the project, uroneurophysiology in the studies of the sacral nervous system lesions, we developed and applied modified clinical neurophysiological methods for assessment of patients with involvement of the sacral neuromuscular system and sacral dysfunctions (lower urinary tract, anorectal, sexual dysfunctions). We have further developed mechanical stimulation to elicit sacral reflexes and cerebral somatosensory evoked potentials in children and have performed several studies to standardise anal sphincter EMG. Among the patients groups studied were boys with enuresis, women with incontinence after vaginal deliveries, and patients with conus and cauda equina lesions. The uroneurophysiological methods developed serve as a clinically useful tool in assessment of lesions in the sacral neuromuscular system. Apart from the use in diagnosis, recording of the bulbocavernosus reflex has proved to be a potentially useful intraoperative monitoring method in patients in whom the sacral nervous system is at risk during surgical procedures. The third part of the project comprises studies on physiological mechanisms of noninvasive electrical and magnetic brain stimulation in man. We examined the corticobulbar influence on the facial muscle motoneurons by studying single motor unit responses. The peristimulus time histogram technique and latency variability of single motor unit responses were used to obtain evidences of monosynaptic cortical projections to the facial motoneurons. The synaptic transmission efficiency at this site was, in comparison to the spinal level, of the same magnitude. In a similar study we found that the facial muscle responses after magntic brain stimulation may at list partially be due also to their reflex activation. The stimulating round coil namely covers a large area of the skull and can concurrently stimulate the motor cortex and the trigeminal nerve sensory afferents which in turn trigger the blink reflex. In the fourth part of the project, molecular genetic studies of the demyelinative type of hereditary motor and sensory polyneuropathy, it was determined that the dominantly inherited CMT1A duplications and HNPP deletions on chromosome 17p11.2 are, as in most other European countries, the most common mutations also in Slovene patients. No signs of polymorphism or potentially recessive mutation were found at the specific Thr118Met PMP22 site.
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