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Projects / Programmes source: ARIS

Expression and function of cholinergic components

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
Keywords
acetylcholinesterase, AChE mRNA, rat skeletal muscle, in vitro innervated human muscle
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publications
1.  11903  PhD Martina Brank  Biotechnology  Researcher  1998 - 2001  28 
2.  05921  Dušanka Čuček  Neurobiology  Researcher  1999 - 2001  3 
3.  07089  Zvonka Frelih    Researcher  1999 - 2001  0 
4.  04410  PhD Zoran Grubič  Neurobiology  Head  1999 - 2001  384 
5.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Researcher  1999 - 2001  1,054 
6.  05046  PhD Majda Zorec-Karlovšek  Neurobiology  Researcher  1998 - 2001  290 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,238 
Abstract
We will study the mechanisms controlling expression of cholinergic components and especially expression of acetylcholinesterase in the mammalian tissues. Various experimental models and tissues such as normal and denervated adult rat muscle, in vitro innervated human muscle, selected parts of the rat central nervous system and rat liver will be employed. Techniques will include: determinations of enzyme activities, in situ hybridization, Northern blotting and cytochemistry of various cholinergic components. We will try to establish at which levels of biosynthetic pathway act the factors known to control acetylcholinesterase expression and what are the mechanisms underlying their action. Mechanisms of acetylcholinesterase inhibition through the peripheral site will be studied by EPR.
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