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Projects / Programmes source: ARIS

Phospholipase a2 in tumor tissue

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Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
P310  Natural sciences and mathematics  Proteins, enzymology 
B200  Biomedical sciences  Cytology, oncology, cancerology 
Keywords
Phospholipase A2, Tumor, Metastasizing
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (7)
no. Code Name and surname Research area Role Period No. of publications
1.  02687  PhD Albert Peter Fras  Oncology  Researcher  1999  271 
2.  18802  PhD Adrijana Leonardi  Biochemistry and molecular biology  Researcher  1997 - 1999  156 
3.  08007  PhD Srdjan Novaković  Oncology  Researcher  1999  496 
4.  12250  PhD Marko Snoj  Oncology  Head  1998 - 1999  195 
5.  09012  Matjaž Šušteršič  Oncology  Researcher  1999  12 
6.  02747  Andreja Zidar  Oncology  Researcher  1999  40 
7.  17285  Darja Žunič Kotar    Researcher  1999  2 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,753 
2.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,472 
Abstract
Intraabdominal spread of malignant tumors is a frequent event in various gynecologic and gastrointestinal tumors and contribute a lot in the morbidity and mortality of these patients. The process of metastasizing is complex and only partialy revealed. The process of intraabdominal metastasizing has some common features that distincts it from general process. Intraabdominal organs are covered with mesothelium which is covered by a thin layer of phospholipids. The attachement of malignant cell cannot be fulfilled if phospholipid layer is not broken. The hydrolysis of phospholipid layer is most probably carried out by phospholipase A2. It seems that phospholipase A2 has an important role in invasion and metastasizing of the malignant tumors of colon and rectum. To show that phospholipase A2 is important in process of intraabdominal metastasizing, its presence and activity should be demonstrated in tumor tissue, harvested from the tumor implants on the peritoneum, when carcinosis of the peritoneum is present. The presence of phospholipase A2 is demonstrated immunohistochemicaly with monoclonal antibodies and by methods of gene engineering. The expresion of mRNA phospholipase A2 is determined by Northern blot technique. The potential outcomes of research project are related to the prevention and development of disease and to improvement of general scientific knowledge.
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