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Projects / Programmes source: ARIS

Immune responses to intrastriatal grafts in the rat

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
Keywords
Rat, neurotransplantation, immune response, xenograft
Evaluation (rules)
source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  11903  PhD Martina Brank  Biotechnology  Researcher  1999  28 
2.  10428  PhD Mara Bresjanac  Neurobiology  Head  1999  250 
3.  17920  Marjeta Dobovišek    Researcher  1999 
4.  10337  PhD Alojz Ihan  Microbiology and immunology  Researcher  1999  1,455 
5.  17923  Vanja Mavrin    Researcher  1999 
6.  17925  Simona Pucihar    Researcher  1998 - 1999 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,429 
Abstract
Although intracerebral transplantation is at the stage of clinical trials, numerous issues of the recipient-graft interactions still await resolution. The proposed research attempts to clarify some aspects of the recipient immune response to an intracerebral graft. Specifically, the aims of the proposed project are: (1) to define the details of the recipient (rat) immune response to cell grafts from donors of a related species (mouse) or unrelated species (hamster or cow), (2) to evaluate a new approach for early detection of graft rejection in vivo, and (3) to study the effects of various manipulations of the immune response using drugs affecting various selected functions of the recipient immune system. The results of the project will ellucidate some major unresolved issues related to the use of neurotransplantation in treatment of neurological disorders, particularly those related to the use of other animal species donor tissues for grafting.
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