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Projects / Programmes source: ARIS

Molecular mechanisms of exocytosis in the pituitary cell

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B480  Biomedical sciences  Endocrinology, secreting systems, diabetology 
Keywords
rat, anterior pituitary, exocytosis, electrophysiology, cytosolic calcium activity, endocytosis, amperometry, molecular cell physiology, membrane capacitance
Evaluation (rules)
source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  06846  Sonja Grilc  Neurobiology  Researcher  2000  57 
2.  01187  PhD Marjan Kordaš  Neurobiology  Researcher  1999 - 2000  293 
3.  18825  PhD Irina Milisav Ribarič  Neurobiology  Researcher  1997 - 2000  154 
4.  12266  PhD Marjan Slak Rupnik  Metabolic and hormonal disorders  Researcher  1998 - 2000  350 
5.  03702  PhD Robert Zorec  Neurobiology  Head  2000  802 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,404 
Abstract
Adenohypophyseal cells functionally integrate the nervous and the endocrine systems. Secretory activity of these cells is controlled by innervation (pars intermedia) or more commonly by circulating hypothalamic regulatory hormones, which after binding to respective specific surface receptors on adenohypophyseal cell membrane, trigger cytosolic signalling mechanisms leading to activation hormone secretion in the process of exocytosis. Secreted hormones reach target tissues and organs via circulation. The study of cytosolic mechanisms of hormone secretion in the pituitary is thus of key importance to understand the integration in the neuroendocrine system. The aim of this project is therefore to study molecular mechanisms of exocytosis in single adenohypophyseal cells. During the last zear we investigated the role of actin, protein CAPS, hetrotrimeric GTP-binding proteins and synaptotagmins in secretory activity of sigle rat melanotrophs.
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