Projects / Programmes
Molecular mechanisms of exocytosis in the pituitary cell
Code |
Science |
Field |
Subfield |
3.03.00 |
Medical sciences |
Neurobiology |
|
Code |
Science |
Field |
B007 |
Biomedical sciences |
Medicine (human and vertebrates) |
B480 |
Biomedical sciences |
Endocrinology, secreting systems, diabetology |
rat, anterior pituitary, exocytosis, electrophysiology, cytosolic calcium activity, endocytosis, amperometry, molecular cell physiology, membrane capacitance
Researchers (5)
Organisations (1)
Abstract
Adenohypophyseal cells functionally integrate the nervous and the endocrine systems. Secretory activity of these cells is controlled by innervation (pars intermedia) or more commonly by circulating hypothalamic regulatory hormones, which after binding to respective specific surface receptors on adenohypophyseal cell membrane, trigger cytosolic signalling mechanisms leading to activation hormone secretion in the process of exocytosis. Secreted hormones reach target tissues and organs via circulation. The study of cytosolic mechanisms of hormone secretion in the pituitary is thus of key importance to understand the integration in the neuroendocrine system. The aim of this project is therefore to study molecular mechanisms of exocytosis in single adenohypophyseal cells. During the last zear we investigated the role of actin, protein CAPS, hetrotrimeric GTP-binding proteins and synaptotagmins in secretory activity of sigle rat melanotrophs.