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Projects / Programmes source: ARIS

Apoptosis and the immune system

Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B500  Biomedical sciences  Immunology, serology, transplantation 
Keywords
apoptosis, immune cells, tumors, infections, immune dependent diseases, healing
Evaluation (rules)
source: COBISS
Researchers (15)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  13302  PhD Jože Cimperman  Microbiology and immunology  Researcher  1997 - 1999 
2.  10337  PhD Alojz Ihan  Microbiology and immunology  Researcher  1997 - 1999 
3.  07766  PhD Staša Kaplan-Pavlovčič  Cardiovascular system  Researcher  1997 - 1999 
4.  08907  Antonija Kotnik  Microbiology and immunology  Researcher  1999 
5.  07756  PhD Vladimir Kotnik  Microbiology and immunology  Head  1997 - 1999 
6.  01982  PhD Radoslav Kveder  Cardiovascular system  Researcher  1997 - 1999 
7.  18077  Jelka Markelj    Researcher  1999 
8.  12193  PhD Manica Mueller Premru  Microbiology and immunology  Researcher  1997 - 1999 
9.  11622  PhD Mario Poljak  Microbiology and immunology  Researcher  1997 - 1999 
10.  13296  PhD Eva Ružić-Sabljić  Microbiology and immunology  Researcher  1997 - 1999 
11.  08800  PhD Gregor Serša  Oncology  Researcher  1998 - 1999 
12.  18075  Tatjana Skočir    Researcher  1999 
13.  13301  PhD Franc Strle  Microbiology and immunology  Researcher  1997 - 1999 
14.  18070  Božena Trampuž    Researcher  1999 
15.  10579  PhD Alenka Urbančič  Cardiovascular system  Researcher  1997 - 1999 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  330 
3.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  62 
Abstract
Apoptosis is physiological process responsible for determination of the living age of an cell. Cells life is perfectly determined and after certain time cells die. Their death depends on several factors including harmful environmental influences or genetically determined factors. Morphologically those two kinds of deaths appears different. Apoptosis is of crucial importance in the time of ontogeny of the immune system. Immune cells with high affinity receptors for self antigens deteriorate on certain step of maturation because not to invade cells of its own organism when they become mature. Maturation of immune cells depends on many factors, some of them are the blood tissue growth factors, others cytokines and still other toxic agents used for the therapy, and some are inducible genetic regulators. The aim of our project is to study phenomenon of apoptosis in presence of tumors, viral or bacterial infection, under influence of cytostatic drug or cytokine therapy and immune dependent diseases. Project is based mainly on an animal model, but some of the data will be obtained also from human patients. Apoptosis phenomena will be followed in normal healthy individuals, in individuals after induction of disease and then in the process of therapy and prevention of disease.
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