Apoptosis and the immune system

Code

J3-8679 (C) - included in ARIS records

Head

PhD Vladimir Kotnik

Period

1/1/1997 - 12/31/1999

Science

Medical sciences (12)
Other (3)

Reseacher status

Researcher (13)
Junior expert or technical associate (2)

Education

Doctor's degree (11)
Other (4)

Sex

Woman (8)
Man (7)

Status

Employed at RO (1)
Employed at RO and RRD (5)
No data on employment in RO (4)
Retired (5)

No. of publications

0 (3)
10–99 (2)
100–999 (7)
1,000–9,999 (3)

Projects / Programmes source: ARIS

source: ARIS

Apoptosis and the immune system

Research activity

Code	Science	Field	Subfield
3.01.00	Medical sciences	Microbiology and immunology

Code	Science	Field
B007	Biomedical sciences	Medicine (human and vertebrates)
B500	Biomedical sciences	Immunology, serology, transplantation

Keywords

apoptosis, immune cells, tumors, infections, immune dependent diseases, healing

Evaluation (rules)

source: COBISS

Evaluation of bibliographic research performance indicators according to ARIS methodology

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (15)

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	13302	PhD Jože Cimperman	Microbiology and immunology	Researcher	1997 - 1999	180
2.	10337	PhD Alojz Ihan	Microbiology and immunology	Researcher	1997 - 1999	1,450
3.	07766	PhD Staša Kaplan-Pavlovčič	Cardiovascular system	Researcher	1997 - 1999	237
4.	08907	Antonija Kotnik	Microbiology and immunology	Researcher	1999	41
5.	07756	PhD Vladimir Kotnik	Microbiology and immunology	Head	1997 - 1999	439
6.	01982	PhD Radoslav Kveder	Cardiovascular system	Researcher	1997 - 1999	296
7.	18077	Jelka Markelj		Researcher	1999	0
8.	12193	PhD Manica Mueller Premru	Microbiology and immunology	Researcher	1997 - 1999	309
9.	11622	PhD Mario Poljak	Microbiology and immunology	Researcher	1997 - 1999	1,217
10.	13296	PhD Eva Ružić-Sabljić	Microbiology and immunology	Researcher	1997 - 1999	551
11.	08800	PhD Gregor Serša	Oncology	Researcher	1998 - 1999	1,511
12.	18075	Tatjana Skočir		Researcher	1999	0
13.	13301	PhD Franc Strle	Microbiology and immunology	Researcher	1997 - 1999	844
14.	18070	Božena Trampuž		Researcher	1999	0
15.	10579	PhD Alenka Urbančič	Cardiovascular system	Researcher	1997 - 1999	81

Organisations (3)

no.	Code	Research organisation	City	Registration number	No. of publicationsNo. of publications
1.	0302	Institute of Oncology Ljubljana	Ljubljana	5055733000	15,455
2.	0312	University Medical Centre Ljubljana	Ljubljana	5057272000	77,422
3.	0381	University of Ljubljana, Faculty of Medicine	Ljubljana	1627066	48,215

Abstract

Apoptosis is physiological process responsible for determination of the living age of an cell. Cells life is perfectly determined and after certain time cells die. Their death depends on several factors including harmful environmental influences or genetically determined factors. Morphologically those two kinds of deaths appears different. Apoptosis is of crucial importance in the time of ontogeny of the immune system. Immune cells with high affinity receptors for self antigens deteriorate on certain step of maturation because not to invade cells of its own organism when they become mature. Maturation of immune cells depends on many factors, some of them are the blood tissue growth factors, others cytokines and still other toxic agents used for the therapy, and some are inducible genetic regulators. The aim of our project is to study phenomenon of apoptosis in presence of tumors, viral or bacterial infection, under influence of cytostatic drug or cytokine therapy and immune dependent diseases. Project is based mainly on an animal model, but some of the data will be obtained also from human patients. Apoptosis phenomena will be followed in normal healthy individuals, in individuals after induction of disease and then in the process of therapy and prevention of disease.