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Projects / Programmes source: ARIS

Boron Neutron Capture Therapy - Employment of drug delivery systems for increased antitumor effectiveness

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Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B200  Biomedical sciences  Cytology, oncology, cancerology 
B140  Biomedical sciences  Clinical physics, radiology, tomography, medical instrumentation 
Keywords
boron neutron capture therapy, electroporation, monoclonal antibodies
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (18)
no. Code Name and surname Research area Role Period No. of publications
1.  15973  PhD Božidar Casar  Physics  Researcher  1998 - 1999  126 
2.  01088  PhD Vladimir Cotič  Biochemistry and molecular biology  Researcher  1997 - 1999  47 
3.  01116  PhD Milan Čerček  Physics  Researcher  1999  318 
4.  04891  Breda Jančar  Oncology  Researcher  1999  36 
5.  10502  PhD Nataša Kopitar Jerala  Biochemistry and molecular biology  Researcher  1997 - 1999  239 
6.  04648  PhD Janko Kos  Biotechnical sciences  Researcher  1997 - 1999  1,158 
7.  04402  Franci-Stanko Marolt  Oncology  Researcher  1997 - 1999  43 
8.  08288  MSc Andrej Plesničar  Oncology  Researcher  1998 - 1999  61 
9.  15974  MSc Vlado Robar  Oncology  Researcher  1998 - 1999  14 
10.  08750  PhD Zvonimir Rudolf  Oncology  Researcher  1999  258 
11.  17096  Andreja Sekirnik  Biochemistry and molecular biology  Researcher  1997 - 1999  30 
12.  08800  PhD Gregor Serša  Oncology  Researcher  1999  1,511 
13.  18359  PhD Janez Ščančar  Control and care of the environment  Researcher  1999  677 
14.  00712  PhD Janez Škrk  Oncology  Head  1997 - 1999  173 
15.  12198  Alenka Vodnik-Cerar  Oncology  Researcher  1997 - 1999  27 
16.  07195  PhD Ivan Vrhovec  Oncology  Researcher  1999  116 
17.  07750  PhD Matjaž Zwitter  Oncology  Researcher  1999  383 
18.  17285  Darja Žunič Kotar    Researcher  1997 - 1999  2 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,664 
2.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,449 
Abstract
The selective accumulation of 10B-containing compounds in tumors and susequent radiation with low-energy (thermal) neutrons forms the basis of boron neutron capture therapy (BNCT). Thermal neutron capture in the stable isotop 10B yields alpha patricles and lithium nuclei, a radiation with short range high linear energy transfer (LET). Therefore, successful implementation of this promising modality strongly depends on the availability of tumor seeking substances or drug delivery systems. In the proposed research project two drug delivery systems were selected to increase antitumor effectiveness of BNCT: the production of monoclonal antibodies specific for tumor cells and electroporation. Both, electroporation and development of specific conjugates with monoclonal antibodies are proposed for further development of antitumor effectiveness of BNCT.
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