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Projects / Programmes source: ARIS

Genetic polymorphisms - candidate genes for coronary artery disease

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Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B790  Biomedical sciences  Clinical genetics 
B530  Biomedical sciences  Cardiovascular system 
Keywords
coronary artery disease, candidate genes, gene polymorphisms of angiotensin convertase, angiotensinogen, angiotensin II type-1 receptor, apoprotein E, apoprotein A1, factor VII, HaeIII beta chain fibrinogen, Bcl I beta chain fibrinogen, factor V point mutation
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (8)
no. Code Name and surname Research area Role Period No. of publications
1.  18263  Miha Elsner    Researcher  1998 - 1999  0 
2.  18266  Nada Godnič    Researcher  1998 - 1999  0 
3.  18267  Andreja Lesar    Researcher  1997 - 1999  0 
4.  03679  Magda Pezdirc    Researcher  1997 - 1999  11 
5.  18268  Danica Šurev    Researcher  1998 - 1999  0 
6.  01862  PhD Olga Vraspir-Porenta  Cardiovascular system  Researcher  1997 - 1999  108 
7.  03287  PhD Marjeta Zorc  Cardiovascular system  Head  1997 - 1999  181 
8.  07797  PhD Rudolfina Zorc-Pleskovič  Cardiovascular system  Researcher  1997 - 1999  138 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,255 
Abstract
Coronary artery disease (CAD) is a complex disease trait, which is probably due to interaction of multiple genetic and environmental factors. Advances in molecular genetics and development of new techniques have led to identification of numerous genetic polymorphisms in candidate genes for CAD. Different genetic polymorphisms- functional variants of candidate genes for CAD were tested in case-control association studies. Candidate genes for CAD are genes, whose protein products are involved in the pathogenesis of atherosclerotic process (renin-angiotensin system and atherogenic factors) and thrombotic process (coagulation cascade). We analyzed 171 Slovenian patients with CAD younger than 55 and compared them with 134 healthy controls. Multiple logistic-regression analysis showed that the deletion/ deletion genotype confers the 2.3 - fold independent risk for CAD in the Slovenian population (95 % confidence interval =1.2-4.3, p < 0.05). Among patients with hypercholesterolemia, a single point mutation in the factor V gene (factor V Leiden) confers the 1.7 - fold independent risk for CAD (95 % confidence interval =1.4-2, p < 0.05). Multiple logistic-regression analysis did not show the gene polymorphisms of the angiotensinogen, angiotensin II type-1 receptor, apoprotein E, apoprotein A1, factor VII beta chain fibrinogen to be independent risk factors for CAD. Polymorphism of the apoprotein E influences the LDL cholesterol level. Individuals with E4/3 genotype have the highest levels of the LDL cholesterol (4.6 mmol/l), individuals with E3/3 genotype have lower LDL cholesterol levels (4.4 mmol/l), individuals with E2/3 genotype having the lowest LDL cholesterol levels (3.4 mmol/l). Multiple logistic-regression analysis showed that the positive family history of CAD confers the 2.4 - fold independent risk for CAD in the Slovenian population. Positive family history of premature CAD confers even higher risk for CAD, the 7.5 - fold independent risk for CAD in the Slovenian population.
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