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Projects / Programmes source: ARIS

Prognostic factors of infertility ii

Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B570  Biomedical sciences  Obstetrics, gynaecology, andrology, reproduction, sexuality 
Keywords
Ovulation induction, ovarian hyperstimulation, low ovarian response, blastomere isolation, systemic and local renin effects, fertilization with spermatids
Evaluation (rules)
source: COBISS
Researchers (22)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  15071  Liljana Bačer Kermavner  Human reproduction  Researcher  1997 - 1999  93 
2.  10568  Sašo Drobnič  Human reproduction  Researcher  1998 - 1999  137 
3.  07652  PhD Vislava Globevnik Velikonja  Human reproduction  Researcher  1998 - 1999  319 
4.  17633  Blanka Gradišek    Researcher  1997 - 1999 
5.  17636  Valerija Jager    Researcher  1998 - 1999 
6.  07437  Davorina Kos-Gril  Human reproduction  Researcher  1998 - 1999 
7.  08772  PhD Helena-Marija Meden-Vrtovec  Human reproduction  Head  1999  614 
8.  17644  Jožica Mivšek    Researcher  1997 - 1999  65 
9.  17645  Zdenka Mramor    Researcher  1997 - 1999 
10.  17647  Andreja Peterlin    Researcher  1997 - 1999 
11.  14534  Mojca Pirc  Human reproduction  Researcher  1998 - 1999  23 
12.  03356  MSc Marija Pompe-Tanšek  Human reproduction  Researcher  1998 - 1999  33 
13.  05274  PhD Martina Ribič Pucelj  Human reproduction  Researcher  1998 - 1999  490 
14.  07007  PhD Tomaž Tomaževič  Human reproduction  Researcher  1997 - 1999  653 
15.  11366  Brigita Valentinčič  Human reproduction  Researcher  1998 - 1999  75 
16.  12245  Alenka Veble  Human reproduction  Researcher  1998 - 1999  71 
17.  05015  PhD Ivan Verdenik  Human reproduction  Researcher  1998 - 1999  481 
18.  06087  PhD Irma Virant Klun  Human reproduction  Researcher  1998 - 1999  523 
19.  06976  PhD Andrej Vogler  Human reproduction  Researcher  1998 - 1999  319 
20.  12177  PhD Eda Vrtačnik-Bokal  Human reproduction  Researcher  1997 - 1999  598 
21.  03447  Žarka Žemva  Human reproduction  Researcher  1998 - 1999  66 
22.  05352  PhD Bojana Žvan  Neurobiology  Researcher  1998 - 1999  804 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,959 
Abstract
Physiological events involved in in vitro and in vivo fertilization will be the basis of our research (6 studies). I. Inhibin A and B as indicators of gonadal activity II. Correlation between implantation ability and uterine artery blood flow in women with polycystic ovarian disease will be studied; besides we shall analyze the critical factor (renin) involved in the development of ovarian hyperstimulation and its local and systemic effects. III. Pathophysiology of severe ovarian hyperstimulation will be evaluated using the analysis of interleukin concentrations in the follicular fluid at the time of premature and in-time aspiration of ovarian follicles in women with exaggerated ovarian response. IV. In low or absent response to ovarian stimulation the discriminatory zone of IGF1 as a marker of ovarian responsiveness will be determined, and growth hormone dependent and independent factors will be analyzed. V. Azoospermia, the condition without spermal cells in the ejaculate, will be studied in patients without spermatozoa in the epididymis and testis. Oocytes will be fertilized with spermatids, i.e. with spermatozoa at the developmental stage having the haploid chromosome set. VI. Preimplantation diagnosis of genetic diseases will be introduced using extra embryos at the three-pronuclear stage (these embryos are rejected in routine procedures). Blastomere isolation using YAG-laser and other methods for blastomere isolation will be used.
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