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Projects / Programmes source: ARIS

Role of lanosterol 14alpha- demethylase in biosynthesis of cholesterol and strols with signalling properties

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Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
P004  Natural sciences and mathematics  Biochemistry, Metabolism 
P320  Natural sciences and mathematics  Nucleic acids, protein synthesis 
Keywords
lanosterol 14alpha-demethylase,cytochrome P450, cholesterol, MAS sterols, spermatogenesis
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (4)
no. Code Name and surname Research area Role Period No. of publications
1.  18992  PhD Martina Fink  Biochemistry and molecular biology  Researcher  1999 - 2001  124 
2.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Researcher  1999 - 2001  1,054 
3.  01043  PhD Peter Lazar  Veterinarian medicine  Researcher  1999 - 2001  74 
4.  06013  PhD Damjana Rozman  Biochemistry and molecular biology  Head  1999 - 2001  887 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,203 
2.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,756 
Abstract
The tissue-specific mechanisms of expression of mammalian CYP51 in liver as the main cholesterogenic organ and testis which show the highest level of CYP51 expression will be studied. The hypothesis that the tissue-specific regulatin of CYP51results in its dual function (cholesterol biosynthesis and synthesis of sterols with signalling properties) will be evalueted. Mouse CYP51 gene will be cloned and CYP51-loxP construct for conditional knockout with the Cre-loxPtechnology prepared. The role of CYP51in spermatogenesis in pig as a large model mammal will be studied.
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