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Projects / Programmes source: ARIS

Hiperhomocisteinemija, dejavnik tveganja za renovaskularno aterosklerotično bolezen ledvic (Slovene)

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B560  Biomedical sciences  Urology, nephrology 
Keywords
homocystein, atherosclerotic stenosis of renal artery, chronic renal insufficiency, end stage renal desease
Evaluation (rules)
source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16363  MSc Nadja Chwatal  Cardiovascular system  Researcher  1999 - 2001 
2.  01975  Andrej Guček  Cardiovascular system  Researcher  1999 - 2001 
3.  07766  PhD Staša Kaplan-Pavlovčič  Cardiovascular system  Head  1999 - 2001 
4.  01982  PhD Radoslav Kveder  Cardiovascular system  Researcher  1999 - 2001 
5.  06203  PhD Marko Malovrh  Cardiovascular system  Researcher  1999 - 2001 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000 
Abstract
Ischaemic renal injury is characterized by a sustained, chronic decrease of arterial blood flow to the kidney in the setting of renovascular atherosclerotic disease and is becoming one of the main causes of end-stage renal disease. Progresion of renal atherosclerosis is critical for prognostic purposes. Prospective studies showed the high prevalence and progressive nature of atherosclerotic lesions at the level of the renal arteries. Renal arterial disease is present in 15% to 23% of patients undergoing cononary angiography and in 45% to 50% of patients undergoing angiography for lower exrremity peripheral vascular disease. The main reason why some patients present with a more rapid deterioration of real function with equivalent degrees of renovascular stenosis and arterial hypertension is still unknown. Multiple studies have shown elevated homocystein levels in patients with cononary, cerebrovascular, or peripheral arterial disease; this association is frequent and independent of most risk factors for atherosclerosis. No date about homocystein as a risk factor for progresive renovascular disease are avaible. In the project we plan to ascertain the prevalence of hyperhomocysteinemia and its value as an indicator of risk in patients with progressive renovascular ischaemic disease. We plan to determine whether vascular disease is related to hyperhomocşteinemia independetly of classic risk factors. Data will be the basic for clinical trials to establish whether vitamin suplementation which reverse high levels of homocystein will affect the evolution of the renovascular occlusive disease.
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