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Projects / Programmes
Malignant disease in arterial hypertension and calcium channel blockers
Research activity
| Code | Science | Field | Subfield |
|---|---|---|---|
| 3.06.00 | Medical sciences | Cardiovascular system |
| Code | Science | Field |
|---|---|---|
| B000 | Biomedical sciences | |
| B530 | Biomedical sciences | Cardiovascular system |
Keywords
apotosis, gen mutation p53, tumours, hypertensive rats, calcium channel blockers
Evaluation
(metodology)
Citations
Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
Organisations (1) , Researchers (5)
0381 University of Ljubljana, Faculty of Medicine
| no. | Code | Name and surname | Research area | Role | Period | No. of publicationsNo. of publications |
|---|---|---|---|---|---|---|
| 1. | 11252 | Cardiovascular system | Researcher | 1998 - 2001 | 328 | |
| 2. | 03679 | Researcher | 1998 - 2001 | 11 | ||
| 3. | 01862 | Cardiovascular system | Researcher | 1998 - 2001 | 108 | |
| 4. | 03287 | Cardiovascular system | Researcher | 1998 - 2001 | 183 | |
| 5. | 07797 | Cardiovascular system | Head | 1998 - 2001 | 140 |
Abstract
The literature data and our experiences suggest that relatively high percentage of tumours are developed in hypertensive patients treated by calcium channel blockers. Our hypothesis is that the reason for tumours development is the primary damage of small vessels caused by the basic disease. This hypothesis will be studied on animal model consisted of spontaneously hypertensive rats. The mutations of tumour suppressor gen p53, the changes in the apoptosis as well as in the walls of small vessels will be studied. The formation of spontaneously malignant tumours in the experimental and control groups of animals will be followed up.