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Projects / Programmes source: ARIS

Razvoj novih antimikrobnih učinkovin na osnovi biotehnoloških in računalniških metod (Slovene)

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Research activity

Code Science Field Subfield
4.06.01  Biotechnical sciences  Biotechnology  Recombinant DNA technology 

Code Science Field
T490  Technological sciences  Biotechnology 
Keywords
antimicrobial drugs, recombinant protein, molecular modeling, DNA gyrase, structure determination, microbial biotechnology
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (7)
no. Code Name and surname Research area Role Period No. of publications
1.  15776  MSc Mojca Golob  Pharmacy  Researcher  1999 - 2001  14 
2.  06628  PhD Roman Jerala  Biochemistry and molecular biology  Head  1999 - 2001  1,189 
3.  04648  PhD Janko Kos  Biotechnical sciences  Researcher  1999 - 2001  1,158 
4.  07084  PhD Andreja Plaper  Pharmacy  Researcher  2000 - 2001  37 
5.  12060  PhD Primož Pristovšek  Chemistry  Researcher  2000 - 2001  135 
6.  01661  PhD Tomaž Šolmajer  Chemistry  Researcher  2000 - 2001  380 
7.  07344  Stanislav Zalar  Pharmacy  Researcher  1999 - 2001  14 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  20,957 
2.  0259  Krka, tovarna zdravil, d.d., Novo mesto (Slovene)  Novo mesto  5043611  3,796 
Abstract
Purpose of the project is to establish a full circle of a development of novel antimicrobial drugs - gyrase inhibitors. The project will integrate biotechnological techniques of cloning and isolation of recombinant bacterial gyrases, computational design of novel drugs based on the tertiary structure of the enzyme, organic synthesis of novel compounds, in vivo and in vitro testing of their inhibition of the gyrase and determination of tertiary structure of complexes by X-ray crystallography and NMR. Goal of the project is the synthesis of a novel gyrase inhibitor based on the rational drug design.
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