Projects / Programmes
Sladkorna bolezen pri otrocih in mladostnikih (Slovene)
| Code |
Science |
Field |
Subfield |
| 3.05.00 |
Medical sciences |
Human reproduction |
|
| Code |
Science |
Field |
| B600 |
Biomedical sciences |
Surgery, orthopaedics, traumatology |
| B480 |
Biomedical sciences |
Endocrinology, secreting systems, diabetology |
IDDM, child, adolescent, genetics, epidemiology, metabolic control, diabetic nephropathy, coeliac disease, education
Researchers (11)
Organisations (3)
Abstract
Children and adolescents are predominantly affected by Type 1 diabetes mellitus (IDDM). The incidence of IDDM in Europe is rapidly increasing especially in the 0 to 15 years age group with an annual rise of 2.5% to 3.6%. Causes for this increase in incidence are not known, but genetic predisposition and environmental factors are thought to play a major role. The onset of IDDM before puberty is associated with more pronounced complications of IDDM, such as diabetic nephropathy. Therefore, the aims of this research project are: 1/ determination of some genetic markers, associated with IDDM, in the population of Slovenian children and adolescents with IDDM; 2/ determination of spatial and temporal distribution of the incidence of IDDM in Slovenia with regard to possible environmental factors; 3/ evaluation of diabetic nephropathy with regard to genetic and intrauterine–predisposing factors, and to long-term metabolic control; 4/ evaluation of concomitant coeliac disease with regard to genetic predisposing factors; 5/ evaluation of the occurrence of hypoglycemia and its impact on the long-term metabolic control; 6/ evaluation of the impact of specialized education, re-education and permanent education on the long-term metabolic control of IDDM. We hypothesize that specific genetic determinants in Slovenian children predispose them to IDDM, and that those genetic determinants have some predictive value. Furthermore, we hypothesize that genetic determinants, intrauterine conditions, environmental factors and long-term control influence the development and progression of complications of IDDM. The results of this research project would contribute to the basic knowledge about IDDM, and provide information for future clinical recommendation in medical care of IDDM.
