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Projects / Programmes source: ARIS

Sladkorna bolezen pri otrocih in mladostnikih (Slovene)

Research activity

Code Science Field Subfield
3.05.00  Medical sciences  Human reproduction   

Code Science Field
B600  Biomedical sciences  Surgery, orthopaedics, traumatology 
B480  Biomedical sciences  Endocrinology, secreting systems, diabetology 
Keywords
IDDM, child, adolescent, genetics, epidemiology, metabolic control, diabetic nephropathy, coeliac disease, education
Evaluation (rules)
source: COBISS
Researchers (11)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  13023  PhD Tadej Battelino  Medical sciences  Head  1999 - 2001  1,254 
2.  01314  MSc Nevenka Bratanič  Human reproduction  Researcher  1999 - 2001  279 
3.  13409  PhD Nataša Bratina  Human reproduction  Researcher  1999 - 2001  433 
4.  02273  PhD Dušan Ferluga  Microbiology and immunology  Researcher  1999 - 2001  531 
5.  02278  PhD Ciril Kržišnik  Human reproduction  Researcher  1999 - 2001  458 
6.  09180  PhD David Neubauer  Oncology  Researcher  1999 - 2001  751 
7.  19252  MSc Mirjam Stopar Obreza  Human reproduction  Researcher  1999 - 2001  39 
8.  20253  PhD Katarina Trebušak Podkrajšek  Human reproduction  Researcher  1999 - 2001  408 
9.  10453  PhD Blanka Vidan-Jeras  Microbiology and immunology  Researcher  1999 - 2001  136 
10.  12955  PhD Nina Zidar  Microbiology and immunology  Researcher  1999 - 2001  391 
11.  15440  PhD Mojca Žerjav Tanšek  Human reproduction  Researcher  1999 - 2001  318 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,904 
2.  0311  Blood Transfusion Centre of Slovenia  Ljubljana  5053960  1,759 
3.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,704 
Abstract
Children and adolescents are predominantly affected by Type 1 diabetes mellitus (IDDM). The incidence of IDDM in Europe is rapidly increasing especially in the 0 to 15 years age group with an annual rise of 2.5% to 3.6%. Causes for this increase in incidence are not known, but genetic predisposition and environmental factors are thought to play a major role. The onset of IDDM before puberty is associated with more pronounced complications of IDDM, such as diabetic nephropathy. Therefore, the aims of this research project are: 1/ determination of some genetic markers, associated with IDDM, in the population of Slovenian children and adolescents with IDDM; 2/ determination of spatial and temporal distribution of the incidence of IDDM in Slovenia with regard to possible environmental factors; 3/ evaluation of diabetic nephropathy with regard to genetic and intrauterine–predisposing factors, and to long-term metabolic control; 4/ evaluation of concomitant coeliac disease with regard to genetic predisposing factors; 5/ evaluation of the occurrence of hypoglycemia and its impact on the long-term metabolic control; 6/ evaluation of the impact of specialized education, re-education and permanent education on the long-term metabolic control of IDDM. We hypothesize that specific genetic determinants in Slovenian children predispose them to IDDM, and that those genetic determinants have some predictive value. Furthermore, we hypothesize that genetic determinants, intrauterine conditions, environmental factors and long-term control influence the development and progression of complications of IDDM. The results of this research project would contribute to the basic knowledge about IDDM, and provide information for future clinical recommendation in medical care of IDDM.
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