Projects / Programmes
Gut microbiota in health and disease
January 1, 2018
- December 31, 2023
| Code |
Science |
Field |
Subfield |
| 3.01.00 |
Medical sciences |
Microbiology and immunology |
|
| 4.06.00 |
Biotechnical sciences |
Biotechnology |
|
| Code |
Science |
Field |
| B000 |
Biomedical sciences |
|
| Code |
Science |
Field |
| 3.01 |
Medical and Health Sciences |
Basic medicine |
| 3.04 |
Medical and Health Sciences |
Medical biotechnology |
gut microbiota, NGS, -omics, metabolome, bacteria, fungi, viruses, phages, healthy volunteers, IBD, gluten, C. difficile, microbe-microbe interactions, dysbiosis, machine learning, complex microbial populations
Data for the last 5 years (citations for the last 10 years) on
June 9, 2023;
A3 for period
2017-2021
| Database |
Linked records |
Citations |
Pure citations |
Average pure citations |
| WoS |
222 |
10,102 |
9,262 |
41.72 |
| Scopus |
224 |
10,975 |
10,030 |
44.78 |
Researchers (14)
Organisations (2)
Abstract
Gut microbiota is a complex microbial community with diverse density and composition throughout the digestive system. Healthy microbiota has significant effect on several aspects of human development and physiology, while dysbiotic microbiota has been associated with many acute and chronic diseases. In this research programme we use different –omics approaches to study bacterial, fungal and viral gut microbiota signatures and functional properties in various patient groups, including individuals with inflammatory bowel disease and with non-celiac gluten sensitivity. Another aspect are studies of microbe-microbe interactions and use of in vitro models. Here our main model is Clostridium difficile infection and especially effect of C. difficile on gut microbiota. Additional large part of the work is devoted to characterization of ‘undefined’ OTUs and their potential role as well as isolation of phages and investigation of their contribution in shaping of the intestinal microbial communities.
Significance for science
Because of its important role and advances in sequencing techniques and analytical algorithms is gut microbiota research currently one of the most rapid developing scientific fields. The work planned within this research programme is expected to contribute to better understanding of structure and function of gut microbiota in some human diseases and to advances in emerging field of microbe-microbe interactions and their role in microbiota associated functions.
Significance for the country
Gut microbiota has either an important function in health maintenance or could be associated with diseases. Hence it represents an emerging diagnostic and therapeutic target. Through understanding of patterns and mechanisms linked to gut microbiota will our work contribute to better diagnostic algorithms or better management of selected diseases or conditions.
The methods and models developed or introduced to local and national research environment will also be used for complementary applications, such as control of multi drug resistant bacteria carriage in the gut reservoir and use of microbiome sequencing for diagnostic purposes (e.g. prosthetic devices, diagnostic samples with low bacterial load).
Development of expertise and international recognition in gut microbiota research will enable participation in international projects, participation at and organizations of congresses and workshops and education of students and researchers at various career stages.
Most important scientific results
Interim report
Most important socioeconomically and culturally relevant results
Interim report
