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Projects / Programmes source: ARIS

Gut microbiota in health and disease

Periods
January 1, 2018 - December 31, 2027
Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   
4.06.00  Biotechnical sciences  Biotechnology   

Code Science Field
B000  Biomedical sciences   

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
3.04  Medical and Health Sciences  Medical biotechnology 
Keywords
gut microbiota, NGS, -omics, metabolome, bacteria, fungi, viruses, phages, healthy volunteers, IBD, gluten, C. difficile, microbe-microbe interactions, dysbiosis, machine learning, complex microbial populations
Evaluation (rules)
source: COBISS
Points
2,547.36
A''
553.1
A'
1,273.85
A1/2
1,764.33
CI10
8,675
CImax
954
h10
46
A1
9.18
A3
28.33
Data for the last 5 years (citations for the last 10 years) on April 14, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender , archive )
Database Linked records Citations Pure citations Average pure citations
WoS  229  10,575  9,714  42.42 
Scopus  240  11,671  10,706  44.61 
Researchers (15)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  54374  PhD Urban Bezeljak  Biochemistry and molecular biology  Researcher  2020 - 2021  15 
2.  50730  Stina Hedžet  Microbiology and immunology  Junior researcher  2018 - 2021  10 
3.  30700  PhD Rosana Hudej  Biotechnology  Researcher  2018 - 2023  26 
4.  33406  PhD Nikolaja Janež  Biochemistry and molecular biology  Researcher  2018  84 
5.  30755  PhD Sandra Janežič  Microbiology and immunology  Researcher  2018 - 2023  155 
6.  37544  PhD Aleksander Mahnič  Microbiology and immunology  Researcher  2018 - 2023  69 
7.  55943  Urša Miklavčič  Microbiology and immunology  Junior researcher  2021 - 2023  10 
8.  54568  Sabina Mlakar    Technical associate  2020 - 2023 
9.  16327  PhD Matjaž Peterka  Biotechnology  Researcher  2018 - 2023  224 
10.  12278  PhD Maja Rupnik  Microbiology and immunology  Head  2018 - 2024  684 
11.  56446  PhD Nejc Stopnišek  Microbiology and immunology  Researcher  2022 - 2023  38 
12.  56353  Vida Štilec  Biotechnology  Researcher  2023  15 
13.  33511  PhD Valerija Tkalec  Microbiology and immunology  Researcher  2021 - 2023  53 
14.  57012  PhD Gordana Uzelac  Biotechnology  Researcher  2022 - 2023 
15.  37161  Tanja Vrabič  Microbiology and immunology  Technical associate  2018 - 2020 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  3030  Center of Excellence for Biosensors, Instrumentation and process Control  Ajdovščina  3660460  946 
2.  3334  National Laboratory of Health, Environment and Foodstaffs  Maribor  6489087  4,595 
Abstract
Gut microbiota is a complex microbial community with diverse density and composition throughout the digestive system. Healthy microbiota has significant effect on several aspects of human development and physiology, while dysbiotic microbiota has been associated with many acute and chronic diseases. In this research programme we use different –omics approaches to study bacterial, fungal and viral gut microbiota signatures and functional properties in various patient groups, including individuals with inflammatory bowel disease and with non-celiac gluten sensitivity. Another aspect are studies of microbe-microbe interactions and use of in vitro models. Here our main model is Clostridium difficile infection and especially effect of C. difficile on gut microbiota. Additional large part of the work is devoted to characterization of ‘undefined’ OTUs and their potential role as well as isolation of phages and investigation of their contribution in shaping of the intestinal microbial communities.
Significance for science
Because of its important role and advances in sequencing techniques and analytical algorithms is gut microbiota research currently one of the most rapid developing scientific fields. The work planned within this research programme is expected to contribute to better understanding of structure and function of gut microbiota in some human diseases and to advances in emerging field of microbe-microbe interactions and their role in microbiota associated functions.
Significance for the country
Gut microbiota has either an important function in health maintenance or could be associated with diseases. Hence it represents an emerging diagnostic and therapeutic target. Through understanding of patterns and mechanisms linked to gut microbiota will our work contribute to better diagnostic algorithms or better management of selected diseases or conditions. The methods and models developed or introduced to local and national research environment will also be used for complementary applications, such as control of multi drug resistant bacteria carriage in the gut reservoir and  use of microbiome sequencing for diagnostic purposes (e.g. prosthetic devices, diagnostic samples with low bacterial load). Development of expertise and international recognition in gut microbiota research will enable participation in international projects, participation at and organizations of congresses and workshops and education of students and researchers at various career stages.
Most important scientific results Interim report
Most important socioeconomically and culturally relevant results Interim report
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