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Projects / Programmes source: ARIS

Modifikacije farmacevtsko pomembnih proteinov za lažjo izolacijo in izboljšanje lastnosti (Slovene)

Research activity

Code Science Field Subfield
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   

Code Science Field
P004  Natural sciences and mathematics  Biochemistry, Metabolism 
P310  Natural sciences and mathematics  Proteins, enzymology 
Keywords
protein, protein engineering, isolation, stabilization, immobilization, renaturation, pharmaceutical use, TNF, analogs, receptor p55, chaperons
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  11108  PhD Marija Anžur-Lasnik  Biotechnology  Researcher  1999 - 2001  32 
2.  06108  PhD Vladimira Gaberc-Porekar  Biotechnology  Head  1999 - 2001  220 
3.  17275  Ana Marija Jesenko    Researcher  1999 - 2001 
4.  16171  PhD Simona Jevševar  Biotechnology  Researcher  1999 - 2001  51 
5.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Researcher  1999 - 2001  1,053 
6.  00385  PhD Nada Kraševec  Biotechnology  Researcher  2000 - 2001  210 
7.  17276  Jelka Lenarčič    Researcher  1999 - 2001 
8.  01494  PhD Viktor Menart  Biotechnology  Researcher  1999 - 2001  162 
9.  00830  PhD Anton Štalc  Biotechnology  Researcher  1999 - 2001  158 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  20,869 
2.  0258  Lek Pharmaceutical Company d.d.  Ljubljana  1732811  8,400 
Abstract
For introductory clinical trials of anti-tumor therapy with our newly developed TNF analogs, a substance of superior quality is needed. Therefore, a thorough study and application of rational approaches of production, including genetic and protein engineering, is necessary. Our project involves study of protein modifications leading to simplified and more economic isolation procedures, simple immobilization on solid supports and new approaches of renaturation. Besides TNF analogs, soluble TNF receptor p55 and chaperon GroEL from E. coli will be used as model molecules.
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