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Projects / Programmes source: ARIS

Phospholipid mediated signal transduction in Aspergillus niger

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Research activity

Code Science Field Subfield
4.06.04  Biotechnical sciences  Biotechnology  Microbe biotechnology 

Code Science Field
T000  Technological sciences   
T490  Technological sciences  Biotechnology 
Keywords
signal transduction, phospholipids, phosphatidylinositol phosphates, diacylglycerol, stress conditions, enzymes
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (2)
no. Code Name and surname Research area Role Period No. of publications
1.  14360  PhD Mojca Benčina  Biotechnology  Researcher  1999 - 2001  392 
2.  06109  PhD Katarina Jernejc  Biotechnology  Head  1999 - 2001  107 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,007 
Abstract
Selected Aspergillus niger strain will be cultivated under optimal conditions and stress conditions with the addition of inositol or specific inhibitor. Quantity and composition of phospholipids will be monitored with emphasis on phosphatidylserine, phosphatidylinositol and phosphatidylinositol phosphates, diacylglycerol and release of intracellular Ca2+. By the obtained results the role of phospholipids in signal transduction pathways will be clarified. We will try to isolate and characterise phosphatidylinositol synthase, the enzyme which catalyses the formation of phosphatidylinositol and CMP from CDP diacylglycerol and inositol. The activity of phospholipase C which converts phosphatidylinositol (4,5) diphosphate into inositol (1,4,5) triphosphate and diacylglycerol-an activator of protein kinase C will be followed.
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