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Projects / Programmes source: ARIS

Role of steroidogenic factor 1 during fetal development

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Research activity

Code Science Field Subfield
4.04.01  Biotechnical sciences  Veterinarian medicine  Morphology, physiology and animal reproduction 

Code Science Field
B005  Biomedical sciences  Zoology 
B350  Biomedical sciences  Development biology, growth (animal), ontogeny, embryology 
Keywords
reproduction, endocrinology, development, testis, adrenal gland, pituitary, hypothalamus, steroidogenic factor-1, transgenesis
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (1)
no. Code Name and surname Research area Role Period No. of publications
1.  13330  PhD Gregor Majdič  Veterinarian medicine  Head  1999 - 2001  577 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,757 
Abstract
Steroidogenic factor 1 (SF-1), isolated as a regulator of the cytochrome P450 steroid hydroxylases, was subsequently shown to play essential roles in endocrine development and function. SF-1 knockout mice lack adrenal glands and gonads, have impaired pituitary gonadotrope function, and lack the ventromedial hypothalamic nucleus (VMH). Ongoing studies seek to expand our understanding of these pleiotropic roles of SF-1. The developing technology for tissue-specific knockouts will allow us to disrupt the gene encoding SF-1 specifically within the VMH, pituitary gonadotropes, Sertoli cells, or granulosa cells.
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