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Projects / Programmes source: ARIS

Early detection of Alzheimer’s disease with the novel biomarkers

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
Keywords
Alzheimer's disease, mild cognitive impairment, visual evoked potentials, magnetic resonance imaging
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publications
1.  53026  Barbara Cussigh  Neurobiology  Technical associate  2020  3 
2.  22466  PhD Irena Hren  Public health (occupational safety)  Researcher  2019 - 2020  172 
3.  29860  PhD Voyko Kavcic  Neurobiology  Researcher  2019 - 2023  161 
4.  38022  Katja Knez  Public health (occupational safety)  Technical associate  2021 - 2023  18 
5.  52549  Sandra Martič  Public health (occupational safety)  Technical associate  2021 - 2023  3 
6.  52123  PhD Marija Menih  Neurobiology  Researcher  2019 - 2023  100 
7.  54152  Zdenka Milič Kavčič  Public health (occupational safety)  Researcher  2020 - 2023  15 
8.  34093  Robert Pintarič  Oncology  Researcher  2019 - 2023  57 
9.  28075  PhD Martin Rakuša  Neurobiology  Head  2019 - 2023  266 
10.  52569  Sofia Rakuša  Neurobiology  Researcher  2019 - 2023  23 
11.  52993  Aljaž Valič  Sport  Researcher  2021 - 2023  21 
12.  52548  Karmen Vizjak Šterman  Neurobiology  Researcher  2019 - 2023  12 
13.  25779  PhD Estera Žalik  Psychiatry  Researcher  2020 - 2023  14 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  23,262 
2.  3873  Mednarodni inštitut za aplikativno gerontologijo d.o.o. (Slovene)  Ljubljana  7295928000  171 
Abstract
Patients with a mild form of Alzheimer's disease (AD) or mild cognitive impairment (MCI) have grey and white matter (WM) impairments, which cause a collapse of the brain networks. This causes the delay of action potentials, which are demonstrated as cognitive decline in various cognitive areas. Among others, it includes disorders of motion detection and attention. Impairment of WM can be non-invasively and objectively demonstrated. We may also find a correlation with the cognitive abilities of the patients. To assess the damage of WM MRI-DTI method can be used. Neurophysiological function of the brain network in visual-spatial and attention tasks can be assessed by visual evoked potentials evoked by motion onset (VEP-MO). Previous studies have used a separate approach. Patients either had MRI or have passed the neurophysiological testing. Our approach will consist of a combination of standard neuropsychological testing, brain MRI and VEP-MO. In this way, we can find new non-invasive biomarkers that would indicate an impairment of cell structures (DTI imaging) and the functioning of the brain network (VEP-MO) in the processing of visual-spatial data and attention. New biomarkers would be included in the battery of tests for the early diagnosis of AD and will contribute to the successful treatment of AD.
Significance for science
With identification of the connections between cortical networks and their functioning, we will introduced at least two new biomarkers of early detection of AD at the international level. Majority of research about the role of local cortical networks in visuospatial processing and attention have been restricted only to single patients group (MCI or AD). With investigation of the visuospatial functioning at patients transitioning from MCI to AD we will directly observe the role of separate fields, and in such way, we will obtain better data that will contribute to the understanding of cortical network functioning. These results could be used in the future. Based on the results we will construct the battery of tests that will be adjusted to individual patient; with such adjustment, we will be able to reach AD diagnosis faster and with noninvasive methods that will enable us to provide better treatment.
Significance for the country
With identification of the connections between cortical networks and their functioning, we will introduced at least two new biomarkers of early detection of AD at the international level. Majority of research about the role of local cortical networks in visuospatial processing and attention have been restricted only to single patients group (MCI or AD). With investigation of the visuospatial functioning at patients transitioning from MCI to AD we will directly observe the role of separate fields, and in such way, we will obtain better data that will contribute to the understanding of cortical network functioning. These results could be used in the future. Based on the results we will construct the battery of tests that will be adjusted to individual patient; with such adjustment, we will be able to reach AD diagnosis faster and with noninvasive methods that will enable us to provide better treatment.
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