Loading...
Projects / Programmes source: ARIS

Novel innovative solutions for diaper rash treatment using diapers with probiotic bacteria

Research activity

Code Science Field Subfield
3.08.00  Medical sciences  Public health (occupational safety)   

Code Science Field
B000  Biomedical sciences   

Code Science Field
3.03  Medical and Health Sciences  Health sciences 
Keywords
diaper rash, diapers for infants, epidemiological study on infants, probiotic bacteria, model systems, electrospinning, nanofibers, 3D printing
Evaluation (rules)
source: COBISS
Researchers (27)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  33666  PhD Vojko Berce  Microbiology and immunology  Researcher  2019 - 2022  227 
2.  51167  Doris Bračič  Textile and leather  Researcher  2021 - 2022  24 
3.  37632  PhD Matej Bračič  Chemistry  Researcher  2021 - 2022  147 
4.  39818  Martina Filipič  Cardiovascular system  Researcher  2019 - 2022  32 
5.  28477  PhD Matjaž Finšgar  Chemistry  Researcher  2019 - 2022  397 
6.  33564  Sonja Golob Jančič  Human reproduction  Researcher  2019 - 2022  56 
7.  20420  PhD Lidija Gradišnik  Neurobiology  Researcher  2019 - 2022  291 
8.  27558  PhD Silvo Hribernik  Textile and leather  Researcher  2021  296 
9.  28976  Tanja Kos    Technical associate  2019 - 2020  42 
10.  24423  PhD Lidija Križančić Bombek  Metabolic and hormonal disorders  Researcher  2019 - 2022  157 
11.  24332  PhD Manja Kurečič  Materials science and technology  Researcher  2019 - 2022  228 
12.  21408  PhD Aleš Lapanje  Microbiology and immunology  Researcher  2019 - 2022  354 
13.  54894  David Majer  Chemistry  Researcher  2020 - 2021  30 
14.  15998  PhD Nataša Marčun Varda  Cardiovascular system  Researcher  2019 - 2022  472 
15.  33260  PhD Tina Maver  Medical sciences  Researcher  2021 - 2022  177 
16.  30850  PhD Uroš Maver  Medical sciences  Head  2019 - 2022  452 
17.  02057  PhD Dušanka Mičetić-Turk  Human reproduction  Researcher  2019 - 2022  1,116 
18.  50675  PhD Marko Milojević  Metabolic and hormonal disorders  Researcher  2019 - 2022  59 
19.  52595  Azra Osmić  Chemistry  Researcher  2022  14 
20.  16340  PhD Uroš Potočnik  Microbiology and immunology  Researcher  2019 - 2022  629 
21.  27542  PhD Tomaž Rijavec  Microbiology and immunology  Researcher  2019 - 2022  247 
22.  52911  Kristijan Skok  Medical sciences  Researcher  2019 - 2022  91 
23.  07814  PhD Karin Stana Kleinschek  Textile and leather  Researcher  2019  1,116 
24.  32141  PhD Janja Stergar  Chemistry  Researcher  2019 - 2021  123 
25.  29591  PhD Maja Šikić Pogačar  Human reproduction  Researcher  2019 - 2022  152 
26.  34307  MSc Lidija Škodič  Chemistry  Researcher  2021  18 
27.  54489  Jernej Vajda  Medical sciences  Junior researcher  2021 - 2022  13 
Organisations (5)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  16,515 
2.  0106  Jožef Stefan Institute  Ljubljana  5051606000  90,682 
3.  0334  University Medical Centre Maribor  Maribor  5054150000  22,744 
4.  0794  University of Maribor, Faculty of Chemistry and Chemical Engineering  Maribor  5089638012  13,112 
5.  0795  University ob Maribor, Faculty of mechanical engineering  Maribor  5089638010  23,905 
Abstract
Based on the newest insights of functioning of human microbiome, we are introducing a breakthrough innovation in the field of treatment and prevention of diaper rash, based on a combination of new, natural, biocompatible and biodegradable carrier materials and either whole microbiome or selected culturable probiotic (commensal) bacteria isolated from healthy skin of babies that will modulate adaptive immune response as well as it will stimulate development of normal healthy microbial communities involved in innate immunity. By developing a laboratory model dressing that will simulate the final product - a diaper, we will test different compositions of carrier materials, and different molecular microbiological approaches either using isolated bacterial strains or whole skin microbiome transplants that will be both obtained and analysed in an epidemiological study on babies bottoms with and without frequent diaper rash occurrence, in order to ensure maximum efficiency in eliminating and preventing diaper rash, while assuring maximum safety for the baby's bottom. Among carrier materials, we will use natural polysaccharides that will, by adequate modification, provide super-absorbency and enable appropriate attachment of probiotic bacteria. Based on these findings, we will develop a prototype diaper incorporating probiotic bacteria and perform all necessary pre-clinical tests facilitating future evaluation in a clinical study.
Significance for science
The proposed project is in many ways unique, namely it combines two rarely intertwined scientific fields, the public health and textile chemistry, as well as innovative by building on and upgrading the existing knowledge in both fields to find novel solutions for a persistent public health problem, namely the diaper rash. The proposed solutions go beyond state-of-the-art in many ways, from the perspective of public health related issues (diaper rash is a very common issue), development of novel treatments for the diaper rash (through use of probiotic bacteria), using the most advanced available techniques in textile chemistry (e.g. electrospinning and 3D printing) and all this with the focus to address a pressing scientific, clinical and industrial problem.   Initially, we will provide insight into the local anogenital microbiome composition of healthy infants and infants with diapers rash. We will use the latest methods in molecular microbiology to not only define, but also to understand this composition. Based on this knowledge and considering the state-of-the-art in regard of the present diaper composition, we will design novel, natural polymer based model diapers using the most advanced available techniques. An important part of our studies will be dedicated to the understanding of interactions between all diaper components, bacteria and skin cells and all this in a simulated physiological environment. All mentioned presents an unique approach of tackling a persisting health related problem and through use of the most modern characterization techniques and methodological approaches, the scientific community will greatly benefit from such an approach and the generated knowledge, paving the way for many other similar studies still to come.   New knowledge will be directly transferred to bachelor, master and PhD students as well as to postdoctoral researchers. Some of the specific actions to be undertaken for the communication and dissemination are listed: i) participation at conferences and scientific meetings on the national, bilateral and international level related to the objectives of the present project, including a positive inclination towards disseminating the results to interested industrial partners, working in similar fields (medicine, chemistry, pharmacy and steel engineering), with whom we could jointly apply for future Horizon 2020 project (and others); ii) publication of scientific articles in highly ranked journals with a broad readership, as well as industrial related journals within the sectors that will be indirectly or consequently involved in the present project; iii) organizing workshops for the dissemination of the resulting technology with the participation of R&D centres from the business associations of the industrial sectors related to the project; iv) scientific networking in order to establish a broad scientific and business network in fields related to the project content.
Significance for the country
The proposed project is in many ways unique, namely it combines two rarely intertwined scientific fields, the public health and textile chemistry, as well as innovative by building on and upgrading the existing knowledge in both fields to find novel solutions for a persistent public health problem, namely the diaper rash. The proposed solutions go beyond state-of-the-art in many ways, from the perspective of public health related issues (diaper rash is a very common issue), development of novel treatments for the diaper rash (through use of probiotic bacteria), using the most advanced available techniques in textile chemistry (e.g. electrospinning and 3D printing) and all this with the focus to address a pressing scientific, clinical and industrial problem.   Initially, we will provide insight into the local anogenital microbiome composition of healthy infants and infants with diapers rash. We will use the latest methods in molecular microbiology to not only define, but also to understand this composition. Based on this knowledge and considering the state-of-the-art in regard of the present diaper composition, we will design novel, natural polymer based model diapers using the most advanced available techniques. An important part of our studies will be dedicated to the understanding of interactions between all diaper components, bacteria and skin cells and all this in a simulated physiological environment. All mentioned presents an unique approach of tackling a persisting health related problem and through use of the most modern characterization techniques and methodological approaches, the scientific community will greatly benefit from such an approach and the generated knowledge, paving the way for many other similar studies still to come.   New knowledge will be directly transferred to bachelor, master and PhD students as well as to postdoctoral researchers. Some of the specific actions to be undertaken for the communication and dissemination are listed: i) participation at conferences and scientific meetings on the national, bilateral and international level related to the objectives of the present project, including a positive inclination towards disseminating the results to interested industrial partners, working in similar fields (medicine, chemistry, pharmacy and steel engineering), with whom we could jointly apply for future Horizon 2020 project (and others); ii) publication of scientific articles in highly ranked journals with a broad readership, as well as industrial related journals within the sectors that will be indirectly or consequently involved in the present project; iii) organizing workshops for the dissemination of the resulting technology with the participation of R&D centres from the business associations of the industrial sectors related to the project; iv) scientific networking in order to establish a broad scientific and business network in fields related to the project content.
Most important scientific results Interim report
Most important socioeconomically and culturally relevant results
Views history
Favourite