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Projects / Programmes source: ARIS

New startegies for fabrication of biomimetic vascular implants

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
nanostructure, biomimetic surface, hemocompatibility, biocompatibility, vascular stent, titanium alloy, surface treatment, gaseous plasma
Evaluation (rules)
source: COBISS
Researchers (18)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  34541  PhD Metka Benčina  Materials science and technology  Researcher  2020 - 2023  79 
2.  52566  PhD Darja Božič  Biotechnology  Researcher  2020  66 
3.  53529  Jernej Ekar  Electronic components and technologies  Junior researcher  2020 - 2023  40 
4.  04634  PhD Aleš Iglič  Systems and cybernetics  Researcher  2020 - 2023  960 
5.  28480  PhD Ita Junkar  Medical sciences  Head  2020 - 2023  285 
6.  15703  PhD Janez Kovač  Electronic components and technologies  Researcher  2020 - 2023  670 
7.  28845  PhD Katja Lakota  Microbiology and immunology  Researcher  2020 - 2023  233 
8.  36461  PhD Luka Mesarec  Physics  Researcher  2020 - 2023  60 
9.  28467  PhD Samo Penič  Electronic components and technologies  Researcher  2022 - 2023  115 
10.  33326  PhD Gregor Primc  Electronic components and technologies  Researcher  2020 - 2023  260 
11.  53323  Anna Romolo    Technical associate  2022 - 2023  38 
12.  53463  PhD Pia Starič  Medical sciences  Junior researcher  2020 - 2023  53 
13.  57380  PhD Szymon Starzonek  Systems and cybernetics  Researcher  2023  36 
14.  13601  PhD Matija Tomšič  Microbiology and immunology  Researcher  2020 - 2023  764 
15.  17622  Janez Trtnik    Technical associate  2020 - 2023  18 
16.  20048  PhD Alenka Vesel  Electronic components and technologies  Researcher  2020 - 2023  686 
17.  34203  PhD Ekaterina Yurieva Gongadze  Neurobiology  Researcher  2020 - 2023  72 
18.  24206  PhD Polona Žigon  Microbiology and immunology  Researcher  2020 - 2023  164 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  89,976 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  76,288 
3.  1538  University of Ljubljana, Faculty of Electrical Engineering  Ljubljana  1626965  27,588 
Abstract
New startegies for fabrication of biomimetic vascular implants Cardiovascular diseases cause millions of deaths all over the world and present a serious health care burden. The minimally invasive way to treat diseased blood vessels is by insertion of expandable tubular stent. Vascular stents have already saved countless lives, but unfortunately their surface properties are still far from optimal. Hence, many research efforts have been directed in optimizing its surface performance. Thus various coating strategies have been developed in order to improve surface properties of so called bare metal stents (BMS) and the new generation of drug eluting stents (DES) was born. The main driving force was to supress rapid smooth muscle cell (SMC) proliferation, which is connected with narrowing of vessel wall (restenosis occurs in 30-50%). It soon became evident that DES could not fully solve this issues, as coatings indeed inhibited growth of SMCs but regrettably growth of ECs was also supressed which increased the risk of thrombosis. Since then various attempts have been made in order to improve surface performance of vascular stents, but unfortunately only incremental improvements were made. The aforementioned issues clearly show that novel surface treatment strategies should be sought. Thus the aim of proposed project directs this issue in particular, as novel approaches for surface treatment are proposed based on biomimetic surfaces, which are inspired from nature and will be fabricated by combination of novel surface treatment techniques; gaseous plasma treatment, hydrothermal treatment and novel plasma anodization method where atmospheric plasma jet will be employed. The first two approaches will be used in combination, while plasma anodization process is novel approach and could be used alone or in combination with gaseous plasma treatment. The main goal is to obtain nanostructured surfaces, which provide guidance to cells and could favour growth of one cell type over another. Surface treatment by highly reactive plasma will be used in order to optimise formation of high quality titanium oxide layers in order to improve biological response and corrosion resistance. The main objectives of the project are: i.) Fabrication of nanostructured-biomimetic surfaces (hydrothermal treatment (HT)) followed by surface chemical modification by low pressure plasma treatment. ii.) Surface modification by low pressure plasma treatment followed by fabrication of nanostructured – biomimetic surfaces (hydrothermal treatment (HT) or plasma anodization). Plasma electrolysis, as a novel approach, will be studied as one step process as it could enable both nanostructuring and surface modification simultaneously. iii.) Optimizing parameters for fabrication of nanostructured-biomimetic surfaces in terms of optimal treatment procedures and treatment conditions used in order to gain desired nanotopography, mechanical stability, corrosion resistance and biological response. iv.) Evaluating different approaches; their variations in nanotopographies and chemistries on the in vitro biological response with SMCs, ECs and whole blood as well as possible commercial use of optimal treatment approach.
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