Projects / Programmes
Lymska borelioza, klopni meningoencefalitis, humana granulocitna erlihioza in druge okužbe pri ljudeh, ki jih prenašajo členonožci v Sl (Slovene)
| Code |
Science |
Field |
Subfield |
| 3.01.00 |
Medical sciences |
Microbiology and immunology |
|
| Code |
Science |
Field |
| B510 |
Biomedical sciences |
Infections |
athropods, ticks, febrile illnesses, Lyme borreliosis, Borrelia burgdoferi sensu lato, Borrelia sensu stricto, Borrelia afzelii, Borrelia garinii, pathogenesis, diagnostics, treatment prevention, human granulocytic ehrlichiosis, tick-borne encephalitis
Researchers (14)
Organisations (1)
Abstract
The research project deals predominantly with Lyme borreliosis but partly also with tick-borne encephalitis and echrlichiosis. Lyme borreliosis is the most frequent tick-transmitted human disease on Northern hemisphere. The incidence in Slovenia is among the highest in Europe. The high frequency and relatively extensive previous knowledge on this disease enable firm basis for further research of several still existing unanswered questions.
Diagnostic value of borrelial intrathecal antibody production will be assessed in patients with cerebrospinal fluid culture proven neuroberreliosis, eventual central nervous system involvement in patients with acrodermatitis chronica atrophicans will be searched for, and the efficacy and safety of doxycycline and ceftriaxone for treatment of patients with acrodermatitis chronica atrophicans but without central nervous system involvement will be assessed. Clinical features, laboratory findings, and etiology in children and adults with erythema migrans will be compared. In two groups of patients with well defined Lyme borreliosis (culture proven erythema migrans and neuroborreliosis) eventual distinctions in clinical and laboratory findings will be searched for according to different etiology (B. afzelii versus B. garinii). The eventual presence of heart involvement eary in the course of Lyme borreliosis will be examined and the influence of azithromycin on Q-T interval will be assessed. In patients with erythema migrans, positive borrelial culture, leukopenia and/or thrombocytopenia the hypothesis on concomitant infection with the human granulocytic ehrlichiosis agent will be tested. Data on the exposure to the agents of Lyme borreliosis, tick-borne encephalitis virus, rickettsiae, and ehrlichiae will be obtained, and the incidence of infection with these agents during one season will be assessed for different part of Slovenia and for groups with different exposure to ticks. The results for B. burgdorferi sensu lato and tick-borne encephalitis virus infection will be compared with findings for the same geographical regions from 10 years ago. The sudy on the etiology of febrile illnesses occurring within six weeks after a tick bite will be continued.
