Chlamydia pneumoniae in koronarna bolezen (Slovene)

Code

J3-2367 (C) - included in ARIS records

Head

PhD Tatjana Lejko-Zupanc

Period

1/1/2000 - 6/30/2002

Range in 2002

0.04 FTE and 314 unpaid hours

Science

Medical sciences (6)

Reseacher status

Researcher (6)
Junior expert or technical associate (0)

Education

Doctor's degree (5)
Master's degree (1)

Sex

Woman (4)
Man (2)

Status

Employed at RO and RRD (3)
Retired (3)

No. of publications

10–99 (1)
100–999 (5)

Projects / Programmes source: ARIS

source: ARIS

Chlamydia pneumoniae in koronarna bolezen (Slovene)

Research activity

Code	Science	Field	Subfield
3.01.00	Medical sciences	Microbiology and immunology

Code	Science	Field
B510	Biomedical sciences	Infections

Keywords

Chlamdyia pneumoniae, serological studies, PCR, acute myocardial infarction, angina pectoris, coronary heart disease, atherosclerosis

Evaluation (rules)

source: COBISS

Evaluation of bibliographic research performance indicators according to ARIS methodology

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (6)

no.	Code	Name and surname	Research area	Role	Period	No. of publicationsNo. of publications
1.	08312	PhD Bojana Beovič	Microbiology and immunology	Researcher	2000 - 2002	462
2.	06311	MSc Janez Kirbiš	Cardiovascular system	Researcher	2000 - 2002	28
3.	04573	PhD Mirta Koželj	Cardiovascular system	Researcher	2000 - 2002	277
4.	08592	PhD Igor Kranjec	Cardiovascular system	Researcher	2000 - 2002	187
5.	11330	PhD Tatjana Lejko-Zupanc	Microbiology and immunology	Head	2000 - 2002	369
6.	16183	PhD Mateja Logar	Microbiology and immunology	Researcher	2000 - 2002	248

Organisations (1)

no.	Code	Research organisation	City	Registration number	No. of publicationsNo. of publications
1.	0312	University Medical Centre Ljubljana	Ljubljana	5057272000	77,499

Abstract

We aim to study seroprevalence of antibodies to Chlamydia pneumoniae and their persistence in patients younger than 45 years with acute coronary event (acute myocardial infarction, new angina pectoris and newly diagnosed coronary heart disease (CHD) on coronarography) and presence of Chlamydia pneumoniae in the wall of ascendent aorta in patients with new unstable angina pectoris. 1. Seroprevalence of infection with Chl. pneumoniae and the role of persistent infection in recurrence of coronary event: Only patients, younger than 45 years having a newly diagnosed CHD will be included. Healthy controls without known CHD, matched by sex, age or smoking status will serve as controls. At least 30 patients and two controls for each patient will be included. At the initial coronary event the presence of antibodies to Chl. pneumoniae (IgA, IgM, IgG) will be determined. Additional serology will be performed after three weeks and twice yearly during regular folow-up for three years. Other known risk factor for CHD, as well as epidemiological data and data on possible new chlamydial infection will be recorded. End point of observation will be a recurrence of coronary event. The two groups will be stratified according to other known risk factors and statistically compared as to the persistence or presence of chlamydial antibodies. 2. Presence of Chl. pneumoniae in ascendent aorta in patients with unstable angina pectoris: 50 patients undergoing coronary by-pass graft for unstable angina will be included. Patients with acquired disease of the aortic valve without CHD will serve as controls. Serological tests will be done at the time of opration and during regular follow-ups twice yearly. Direct immunoflourescence and PCR will serve as a method of proving the presence of Chl. pnumoniae in the aortic wall. End point of observation will be recurrence of angina, acute myocardial infarction or restenosis. Multivariate analysis will be used for statistical analysis and to exclude confounding by other known risk factor for CHD.