Nevroendokrino uravnavanje tonusa koronarnega žilja (Slovene)

Code

J3-2389 (D) - included in ARRS records

Head

PhD Matjaž Bunc

Period

1/1/2000 - 6/30/2002

Range in 2002

0.07 FTE

Science

Engineering sciences and technologies (2)
Medical sciences (2)

Reseacher status

Researcher (3)
Junior expert or technical associate (1)
Junior researcher (0)
Researcher/expert (0)
Private researcher (0)

Education

Doctor's degree (3)
Other (1)

Sex

Woman (1)
Man (3)

Status

Active (4)

No. of publications

100–999 (4)

Projects / Programmes source: ARRS

source: ARRS

Nevroendokrino uravnavanje tonusa koronarnega žilja (Slovene)

Research activity

Code	Science	Field	Subfield
3.03.00	Medical sciences	Neurobiology

Code	Science	Field
B640	Biomedical sciences	Neurology, neuropsychology, neurophysiology
B530	Biomedical sciences	Cardiovascular system

Keywords

coronary vascular tonus, in vivo stimulation of vegetative nervus system, isolated coronaries, endothelium cell cultures, actinoporins, dynamics of intracellular calcium activity, endothelium released mediators, endothelin I

Evaluation (rules)

source: COBISS

Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases

source: WoS

source: Scopus

source: COBISS

Researchers (4)

no.	Code	Name and surname	Research area	Role	Period	No. of publications
1.	15667	PhD Matjaž Bunc	Neurobiology	Principal Researcher	2000 - 2002	508
2.	04293	PhD Janez Rozman	Systems and cybernetics	Researcher	2000 - 2002	244
3.	09861	Jerneja Strupi-Šuput	Civil engineering	Researcher	2000 - 2002	134
4.	07002	PhD Dušan Šuput	Neurobiology	Researcher	2000 - 2002	423

Organisations (2)

no.	Code	Research organisation	City	Registration number	No. of publications
1.	0381	University of Ljubljana, Faculty of Medicine	Ljubljana	1627066	44,779
2.	1326	ITIS, Implantable Technology and Sensors, producing, trading, servicing and researching enterprise, d.o.o. Ljubljana	Ljubljana	5824796000	244

Abstract

Atherosclerosis is the main cause of myocardial ischemic events. Less often coronary vasospasm could be also the cause of myocardial ischemia but the mechanism is still obscure. We suppose that endothelial dysfunction should be involved in the mechanism of coronary vasospasm, but the importance of vegetative nervous system is unknown. We are going to provide stimulation of both parasympathic and sympathic nerve system in a dog animal model. The main goal of our experiments is to find out the influence of chronic intermitent stimulation of stellat ganglions and vagal nerve on morfologic changes of coronary arteries and appearance of coronary vasospasm. Interactions between endothelium and vascular smooth muscle will be studied on rings of isolated pig coronaries. Equinatoxin II, actinoporin isolated from the sea anemone Acinia equina (L.), will be used as a kind of biological tool for the releasing of vasoactive substances from endothelium. Through the modulation of the effects of released mediators by different blocker of the endotehlial function (methylen blue, indomethacin) and receptors on vascular smooth muscle (calcium channel blocker type L, endothelin receptorsblockers), the mechanism of contraction caused by equinatoxin II will be studied. Equinatoxin II will be used as biological tool for paracrine releasing of endotelin I. The last mentioned effect of equinatoxin II will be used for testing of potency of different available blockers of endotelin receptors. Intracellular activity of calcium ions and morphologic changes of endotehlial cell cultures due to the toxin action will be studied too. Simultaneouslly with the measurements of intracellular calcium activity we are going to measure releasing of NO, endothelin I and products of arachidonic acid metabolism.