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Vloga katepsinov in njihovih inhibitorjev v napredovanju možganskih tumorjev: celični modeli in vitro in klinična uporaba v prognozi,.. (Slovene)

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B200  Biomedical sciences  Cytology, oncology, cancerology 
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
Keywords
Brain cancer, prognosis, microsatellites, cysteine cathepsins, stefins
Evaluation (rules)
source: COBISS
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publications
1.  02710  PhD Vinko Vincenc Dolenc  Medical sciences  Head  2000 - 2002  236 
2.  07802  PhD Tamara Lah Turnšek  Natural sciences and mathematics  Researcher  2000 - 2002  1,012 
3.  17003  PhD Nataša Levičar  Natural sciences and mathematics  Researcher  2000 - 2002  42 
4.  16193  Nataša Sever  Natural sciences and mathematics  Researcher  2000 - 2002  30 
5.  18471  PhD Andrej Vranič  Medical sciences  Researcher  2000 - 2002  59 
6.  10974  PhD Irena Zajc  Natural sciences and mathematics  Researcher  2000 - 2002  134 
Organisations (2)
no. Code Research organisation City Registration number No. of publications
1.  0105  National Institute of Biology  Ljubljana  5055784  13,066 
2.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  74,721 
Abstract
It is known that an imbalance between cathepsins and their inhibitors in brain tumors correlates with the malignancy, while cathepsin B in glioblastoma correlates with shorte survival. We will measure cathepsins B and L, stefins A and B, and cystatin C in brain tumor cell lines of different malignancy and investigate the possibilities to inhibit their unvasiveness in vitro. In clinical stidies, we will determinate these enzymes in tissue homogenates and in histological sections and correlate them with genetic instability, prognosis, and patients'' response to chemotherapy.
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