Projects / Programmes source: ARIS

MIcrofluidic Sensor System for PESticides detection (MISS PES)

Research activity

Code Science Field Subfield
2.09.00  Engineering sciences and technologies  Electronic components and technologies   

Code Science Field
2.05  Engineering and Technology  Materials engineering 
neonicotinoides, electrochemical sensors, thick films, nanostructures, graphene, LTCC, microfluidics
Evaluation (rules)
source: COBISS
Data for the last 5 years (citations for the last 10 years) on June 17, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Database Linked records Citations Pure citations Average pure citations
WoS  530  12,138  10,558  19.92 
Scopus  564  13,365  11,600  20.57 
Researchers (16)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  19038  PhD Andreja Benčan Golob  Materials science and technology  Researcher  2021 - 2024  537 
2.  57149  Izabela Čurković    Technical associate  2022 - 2024  10 
3.  56886  Maksimiljan Dekleva  Chemistry  Junior researcher  2022 - 2024  21 
4.  06896  Silvo Drnovšek    Technical associate  2021 - 2024  306 
5.  25788  PhD Boštjan Genorio  Materials science and technology  Researcher  2021 - 2024  327 
6.  51846  PhD Ema Gričar  Chemistry  Junior researcher  2021 - 2022  40 
7.  30036  Brigita Kmet    Technical associate  2021 - 2023  169 
8.  16429  PhD Mitja Kolar  Chemistry  Researcher  2021 - 2024  614 
9.  13369  PhD Danjela Kuščer Hrovatin  Electronic components and technologies  Head  2021 - 2024  541 
10.  32155  PhD Kostja Makarovič  Electronic components and technologies  Researcher  2021 - 2024  173 
11.  34599  PhD Gregor Marolt  Chemistry  Researcher  2021 - 2024  136 
12.  13530  PhD Helena Prosen  Chemistry  Researcher  2021 - 2024  444 
13.  55725  Barbara Repič  Materials science and technology  Junior researcher  2022 - 2024  22 
14.  38295  PhD Ana Robba  Chemistry  Researcher  2021 - 2024  40 
15.  52065  PhD Matej Šadl  Electronic components and technologies  Junior researcher  2021 - 2022  100 
16.  26468  PhD Hana Uršič Nemevšek  Electronic components and technologies  Researcher  2021 - 2024  659 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0106  Jožef Stefan Institute  Ljubljana  5051606000  91,415 
2.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,304 
Neonicotinoid pesticides (NNIs) are a group of comparatively new, broad-spectrum insecticides that affect the central nervous system of insects, leading to eventual paralysis and death. NNIs are one of the most used pesticides worldwide, due to their effectiveness and relatively low toxicity towards non-target species. But some recent research shows that NNIs could affect the mammalian nervous system, and could cause colony collapse in honeybees. All NNIs are toxic to honeybees, with oral LD50 values below 5 ng per honeybee. To protect honeybees and thus to preserve biodiversity in the environment, the European Commission imposed a ban on the use of the three most toxic NNIs in 2018. Due to the environment and food-safety issue, the monitoring of NNIs in real samples has become increasingly important. The chromatography/mass-spectrometry techniques are well established and reliable, but they are performed in laboratories, are time-consuming, demand the use of expensive equipment and require highly trained staff. There is urgent need to provide accurate, selective and sensitive determinations of NNIs on-site in real samples. In the project we propose to design and develop a microfluidic electrochemical sensor (MES) system that will enable the simultaneous detection and quantification of five relevant NNIs with a ng/g limit of detection without the use of expensive equipment and lengthy procedures. The objectives of the project are: 1) Preparation of a graphene-based/metal or metal-oxide nanoparticle composite working electrodes for detecting NNIs and evaluation of the selectivity and sensitivity of the electrode in a three-electrode system; 2) Fabrication of a microfluidic electrochemical sensor system for the detection of multiple NNIs and determination of the measuring conditions for the sensing five different NNIs, each separately, in a model fluid; 3) Determination of five NNIs using a microfluidic electrochemical sensor (MES) system in a relevant environment (surface water and honey) with a detection limit below 1 ng/g. To achieve these objectives, we will design the microfluidic electrochemical sensor system from low-temperature cofired ceramics (LTCC) or polymer with an array of individual three-electrode system (TES) sensors. The sensing principle is based on voltammetry. All the electrodes and interconnections for TES will be processed on alumina or low-temperature cofired ceramics (LTCC) using screen-printing technology. The working electrode made from Au or carbon will be modified by graphene-based nanostructured materials, gold and Co- or Bi-oxides nanoparticles to fine-tune its electrochemical response. The printing technology (inkjet-, screen-) following by drying/heating will be utilised for the WE’s modification to obtain a thickness-uniform, homogeneous layer that will improve the process reproducibility and measurement repeatability. Each sensor will be calibrated for a different NNI. The performance of the device will be validated with respect to its analytical parameters. Furthermore, it will be tested on surface water and honey, and the results will be compared to the results of the established solid-phase extraction/liquid chromatography/mass spectrometric method.
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