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Projects / Programmes source: ARIS

Controlled generation of microbubbles and exploration of their physics for exploitation in chemistry, biology and medicine

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Research activity

Code Science Field Subfield
2.21.00  Engineering sciences and technologies  Technology driven physics   

Code Science Field
1.03  Natural Sciences  Physical sciences 
Keywords
Cavitation, bubble, laser, microscale, sonoporation
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Points
6,622.92
A''
3,919.38
A'
5,109.16
A1/2
5,862.71
CI10
4,631
CImax
214
h10
38
A1
27.58
A3
11.9
Data for the last 5 years (citations for the last 10 years) on April 25, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Database Linked records Citations Pure citations Average pure citations
WoS  225  5,107  4,222  18.76 
Scopus  247  5,912  4,959  20.08 
Researchers (12)
no. Code Name and surname Research area Role Period No. of publications
1.  32091  PhD Vid Agrež  Technology driven physics  Researcher  2021 - 2024  87 
2.  23471  PhD Matevž Dular  Energy engineering  Head  2021 - 2024  462 
3.  54520  PhD Parham Kabirifar  Process engineering  Researcher  2022 - 2024  16 
4.  37513  PhD Žiga Lokar  Manufacturing technologies and systems  Researcher  2022 - 2024  37 
5.  34009  Aleš Malneršič  Process engineering  Researcher  2021 - 2024  74 
6.  37953  PhD Jaka Mur  Manufacturing technologies and systems  Researcher  2021 - 2024  52 
7.  36989  Uroš Orthaber  Technology driven physics  Researcher  2021 - 2024  12 
8.  35069  PhD Martin Petkovšek  Process engineering  Researcher  2021 - 2024  133 
9.  15646  PhD Rok Petkovšek  Manufacturing technologies and systems  Researcher  2021 - 2024  273 
10.  39917  Matej Sečnik  Process engineering  Researcher  2023 - 2024  61 
11.  52620  PhD Jure Zevnik  Process engineering  Researcher  2021 - 2024  35 
12.  33926  PhD Mojca Zupanc  Process engineering  Researcher  2023 - 2024  78 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0782  University of Ljubljana, Faculty of Mechanical Engineering  Ljubljana  1627031  29,252 
Abstract
Cavitation, i.e. the appearance of vapour cavities inside an initially homogeneous liquid medium, occurs if the pressure is lowered below vapour pressure. The vapour structures are unstable, and when they reach a region of increased pressure, they often collapse violently. Following this, engineers need to deal with various nuisances, but on the other hand, studies have also shown that there is a great potential to utilize cavitation in various important applications in the fields of biology, chemistry, medicine and in environmental protection Remarkably little is known about which or a combination of which mechanisms is important for a specific consequence of cavitation. Thousands of papers have been devoted to the subject of bubbles, however, the exact mechanism induced by bubbles has not yet been elucidated The project consortium consists of two laboratories, led by Matevž Dular (PI of the proposed project), who was in 2017 awarded an ERC Consolidator Grant, for a work which employs an unconventional synergetic interdisciplinary approach to pioneer the research of the basic mechanisms, which take place during the interaction between bubbles and contaminants (bacteria and viruses) and Rok Petkovsek (Co-PI of the proposed project), who leads a team in developing laser systems and has recently made breaktroughs in high speed and high resolution visualization of cavitation bubbles. Both teams work closely together and have several common publications in the last 2 years. Recent reports point to the fact that the dynamics of microscopic cavitation bubbles differs significantly from the ones at larger scales. However experimental investigations of the former in a precisely controlled environment, are still beyond the current state of the art. To address this issue, we will develop a new facility which enables generation of microscopic cavitation bubbles. In parallel a significantly improved observation system will be developed, which will increase both the spatial and temporal resolution of the existing experiments. The overall objective of the project is to understand and determine the fundamental physics of the interaction of microscopic cavitation bubbles. The experimental work will be complemented by numerical simulations which will enable extrapolation of the results beyond the capabilities of the experiments. The proposed approach builds on the PI's preliminary research in the scope of ERC grant and employs novel experimental and numerical methodologies, which have been developed by the PI and the Co-PI and their research group. The current project proposal intends to employ novel techniques for bubble generation and monitoring in order to breach the gap to experimental observation of microscale bubbles The main objectives of the proposed project are: Development and optimization of a first of its kind facility, which will enable the research of the dynamics of microscopic cavitation bubbles.Investigation of the dynamics of microscopic cavitation bubbles in near “infinite” environment.Investigation of the dynamics of microscopic cavitation bubbles in the presence of surface-active substances, with a clear aim to the deeper understanding of the physics of processes of sonoporation (targeted drug delivery) and emulsification (nano emulsion processing).Investigation of the dynamics of microscopic cavitation bubbles in highly anisotropic environment. Our preliminary numerical studies of such bubbles point to the possibility that the dynamics at small scales differs significantly from the macroscopic ones. This will be investigated with a vision of optimization of a posteriori capsulotomy (eye lens surface cleaning).
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