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Projects / Programmes source: ARIS

The impact of various surgical techniques on the molecular mechanisms of gynecological cancer metastasis.

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
pneumoperitoneum, laparoscopy, tumor dissemination, cervical cancer, endometrial cancer, uterine manipulator
Evaluation (rules)
source: COBISS
Points
14,244.82
A''
1,497.74
A'
5,764.78
A1/2
8,709.09
CI10
26,979
CImax
3,408
h10
60
A1
48.65
A3
17.61
Data for the last 5 years (citations for the last 10 years) on July 23, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Database Linked records Citations Pure citations Average pure citations
WoS  871  28,041  25,826  29.65 
Scopus  840  31,589  29,243  34.81 
Researchers (44)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  14114  PhD Darja Arko  Oncology  Researcher  2021 - 2024  324 
2.  55524  Maša Brumec  Oncology  Researcher  2022 - 2023 
3.  29835  PhD Tomaž Budefeld  Microbiology and immunology  Researcher  2021 - 2024  92 
4.  38285  Andrej Cokan  Human reproduction  Researcher  2021 - 2024  102 
5.  37203  Bojana Crnobrnja  Human reproduction  Researcher  2021 - 2024  47 
6.  20133  Nina Čas Sikošek  Oncology  Technical associate  2021 - 2024  85 
7.  36818  PhD Helena Sabina Čelešnik  Biochemistry and molecular biology  Researcher  2021 - 2024  61 
8.  54490  Laura Činč Ćurić  Pharmacy  Researcher  2021 - 2024  19 
9.  23415  PhD Jurij Dolenšek  Metabolic and hormonal disorders  Researcher  2021 - 2024  236 
10.  37711  PhD Andraž Dovnik  Oncology  Researcher  2021 - 2024  137 
11.  26010  PhD Boris Gole  Biochemistry and molecular biology  Researcher  2021 - 2024  77 
12.  07616  MSc Maksimiljan Gorenjak  Human reproduction  Researcher  2021 - 2024  206 
13.  33268  PhD Mario Gorenjak  Biochemistry and molecular biology  Researcher  2021 - 2024  168 
14.  34478  PhD Larisa Goričan  Microbiology and immunology  Researcher  2021 - 2024  37 
15.  32509  Kristina Gornik Kramberger  Oncology  Researcher  2021 - 2024  42 
16.  20420  PhD Lidija Gradišnik  Neurobiology  Researcher  2021 - 2024  294 
17.  39347  PhD Marko Hojnik  Oncology  Researcher  2022 - 2024  19 
18.  29880  Suzana Hunjadi    Researcher  2022 - 2024 
19.  39240  PhD Gregor Jezernik  Microbiology and immunology  Researcher  2021 - 2024  43 
20.  10772  PhD Rajko Kavalar  Oncology  Retired researcher  2021 - 2024  253 
21.  33092  PhD Jure Knez  Human reproduction  Researcher  2021 - 2024  207 
22.  38022  Katja Knez  Public health (occupational safety)  Technical associate  2021 - 2024  18 
23.  15712  Martina Kos  Public health (occupational safety)  Technical associate  2021 - 2024  40 
24.  38452  PhD Nejc Kozar  Oncology  Researcher  2021 - 2024  108 
25.  11699  PhD Tea Lanišnik Rižner  Metabolic and hormonal disorders  Researcher  2021 - 2024  580 
26.  55167  Živa Ledinek  Oncology  Researcher  2022 - 2024  28 
27.  54498  Nadja Lubajnšek  Oncology  Researcher  2022 - 2024  14 
28.  52198  Lara Lukman  Human reproduction  Researcher  2021 - 2023 
29.  52549  Sandra Martič  Public health (occupational safety)  Technical associate  2021 - 2024 
30.  30850  PhD Uroš Maver  Medical sciences  Researcher  2021 - 2024  456 
31.  51035  Milena Mikluš  Oncology  Researcher  2021 - 2023 
32.  50675  PhD Marko Milojević  Metabolic and hormonal disorders  Researcher  2021  60 
33.  39524  PhD Viljem Pohorec  Metabolic and hormonal disorders  Researcher  2021 - 2024  69 
34.  16340  PhD Uroš Potočnik  Microbiology and immunology  Researcher  2021 - 2024  634 
35.  34259  PhD Maša Sinreih  Biochemistry and molecular biology  Researcher  2021 - 2024  88 
36.  57289  Damjan Sisinger  Oncology  Researcher  2022 - 2024 
37.  29565  PhD Maša Skelin Klemen  Metabolic and hormonal disorders  Researcher  2021 - 2024  152 
38.  52911  Kristijan Skok  Medical sciences  Researcher  2021 - 2023  91 
39.  50187  PhD Monika Sobočan  Oncology  Researcher  2021 - 2024  226 
40.  32132  PhD Andraž Stožer  Metabolic and hormonal disorders  Researcher  2021 - 2024  432 
41.  01324  PhD Iztok Takač  Human reproduction  Head  2021 - 2024  920 
42.  54489  Jernej Vajda  Medical sciences  Junior researcher  2021 - 2024  14 
43.  52993  Aljaž Valič  Sport  Researcher  2021 - 2024  21 
44.  56550  Damjan Vidovič    Researcher  2022 - 2024 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0334  University Medical Centre Maribor  Maribor  5054150000  23,150 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,762 
3.  2334  University of Maribor, Faculty of Medicine  Maribor  5089638048  15,956 
Abstract
The impact of minimally invasive surgical techniques, especially the influence of CO2 pneumoperitoneum and manipulator use in cervical cancer treatment is currently under investigation due to poor overall survival in comparison to open surgery for cervical cancer. Recent multi-centric research showed, that patients treated for cervical cancer with a laparoscopic approach had a higher risk of recurrence and worse overall survival than women treated with open surgery. The surprising outcome was unique for cervical cancer, as prior clinical research in endometrial cancer showed no such adverse events in comparing techniques. With no obvious explanation into the outcome difference, treatment options must be assessed through their mechanism of action. A possible route of tumor dissemination during surgery is therefore the use of CO2 pneumoperitoneum and use of a uterine manipulator. CO2 pneumoperitoneum has been assessed previously in studies with contradictory results. The preclinical understanding of tumor spillage by a uterine manipulator however has never even been attempted. Therefore this project aims to: i) identify alterations present in cancer cells exposed to CO2 by the use of cell culture gene expression analysis and RNA-seq; ii) understand the mechanistic background of immunological and pro-inflamatory events by means of identifying matrix components behavior and adhesion molecules (Western blot and RT-PCR); iii) develop a surgically-mechanistic in-vitro model by developing an in-vitro real time simulation of “shearstress ”and “mechanical stress”. Our model of exploration enables a comprehensive understanding of the factors involved, focusing on global gene expression in response to CO pneumoperitoneum, targeted molecular interactions, changes in cell-cell communication, as well as the development of a possibly more precise model of simulation with the use of a manipulator for adding pressure on the cancerous cells. Thus enabling us to assess the impact of laparoscopy on tumor dissemination and lead to evidence based decision making in clinical treatment of gynecological cancers.
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