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Projects / Programmes source: ARIS

The EB adhesome as potential target for new therapy approaches

Research activity

Code Science Field Subfield
3.07.00  Medical sciences  Metabolic and hormonal disorders   

Code Science Field
3.02  Medical and Health Sciences  Clinical medicine 
Keywords
regenerative medicine, iPSC, 3D tissue models, adhesome, extracellular matrix, epidermolysis bullosa, mass spectrometry
Evaluation (rules)
source: COBISS
Points
1,973.79
A''
1.08
A'
261.75
A1/2
882.68
CI10
12,161
CImax
6,816
h10
17
A1
6.02
A3
0.67
Data for the last 5 years (citations for the last 10 years) on July 21, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Database Linked records Citations Pure citations Average pure citations
WoS  145  9,706  9,473  65.33 
Scopus  140  11,851  11,582  82.73 
Researchers (6)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16104  PhD Apolonija Bedina Zavec  Biotechnology  Researcher  2021 - 2024  154 
2.  14305  PhD Mirjana Liović  Metabolic and hormonal disorders  Head  2021 - 2024  149 
3.  34353  PhD Marija Rogar  Biochemistry and molecular biology  Researcher  2021 - 2024  25 
4.  55720  Tjaša Sorčan Snedec  Biochemistry and molecular biology  Researcher  2021 
5.  26234  PhD Špela Zemljič Jokhadar  Neurobiology  Researcher  2021 - 2024  53 
6.  53996  Milanka Živanović  Oncology  Technical associate  2021 - 2024 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,743 
2.  0104  National Institute of Chemistry  Ljubljana  5051592000  21,271 
Abstract
Epidermolysis bullosa (EB) is a disfiguring and debilitating hereditary skin fragility disorder consisting of four major subtypes. It is caused by mutations affecting 18 structural proteins of the skin. As these proteins have a unique role of providing structural support to cells and adhesion to the different skin layers, mutations impair their structure and function and result in fragile skin that blisters easily and severely, often causing open wounds. In dystrophic EB (DEB) mutations affect collagen VII, which helps anchor the top layer of skin. The adhesome is a term incorporating all structural and signaling proteins involved in cell adhesion. Very little is known about the adhesome in EB. We believe that by determining the EB adhesome and by comparing it to healthy cells, we will learn more about the function of the adhesome, the EB disease mechanisms involved and how this may be linked to squamous cell carcinoma development, which is the major cause of death in recessive DEB patients. To achieve this, we are basing this project on cutting edge biotechnology techniques, such as mass spectrometry, induced pluripotent stem cell technology and the generation and testing on our own in vitro 3D full skin equivalents for EB.
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