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Projects / Programmes source: ARIS

Laser assisted removal of biofilms associated with periodontal and peri-implant diseases

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Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   
4.06.00  Biotechnical sciences  Biotechnology   

Code Science Field
3.01  Medical and Health Sciences  Basic medicine 
3.04  Medical and Health Sciences  Medical biotechnology 
Keywords
Periodontitis, peri-implantitis, biofilm removal, Er:YAG laser, photoacoustic irrigation, photodynamic therapy, photothermal therapy, constricted 3D geometries, cavitation.
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Points
5,435.36
A''
2,189.7
A'
3,068.31
A1/2
4,403.99
CI10
5,840
CImax
270
h10
42
A1
20.95
A3
5.62
Data for the last 5 years (citations for the last 10 years) on April 23, 2024; A3 for period 2018-2022
Data for ARIS tenders ( 04.04.2019 – Programme tender, archive )
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Database Linked records Citations Pure citations Average pure citations
WoS  287  7,067  6,065  21.13 
Scopus  313  8,230  7,087  22.64 
Researchers (19)
no. Code Name and surname Research area Role Period No. of publications
1.  11905  PhD Aleš Babnik  Manufacturing technologies and systems  Researcher  2021 - 2024  103 
2.  56005  Tine Brežan  Manufacturing technologies and systems  Researcher  2022 - 2024  0 
3.  12446  PhD Boris Gašpirc  Stomatology  Researcher  2021 - 2024  163 
4.  29224  PhD Peter Gregorčič  Manufacturing technologies and systems  Researcher  2021 - 2024  263 
5.  50212  PhD Luka Hribar  Manufacturing technologies and systems  Researcher  2022 - 2024  22 
6.  33345  PhD Nina Hropot Pleško  Stomatology  Researcher  2021 - 2024  9 
7.  21238  PhD Matija Jezeršek  Manufacturing technologies and systems  Researcher  2021 - 2024  375 
8.  38896  PhD Matjaž Kos  Manufacturing technologies and systems  Researcher  2022 - 2024  27 
9.  39927  PhD Jure Košir  Systems and cybernetics  Researcher  2021  14 
10.  22492  PhD Barbara Kraigher  Biology  Researcher  2021 - 2024  122 
11.  29435  PhD Špela Levičnik Hoefferle  Biotechnology  Researcher  2021 - 2024  24 
12.  09757  PhD Matjaž Lukač  Physics  Researcher  2021 - 2024  184 
13.  39099  PhD Katja Molan  Biochemistry and molecular biology  Researcher  2021 - 2024  41 
14.  39579  Rok Ovsenik  Stomatology  Researcher  2021 - 2024  21 
15.  12137  PhD Rok Schara  Stomatology  Researcher  2021 - 2024  115 
16.  52342  Matej Senegačnik  Manufacturing technologies and systems  Technical associate  2021 - 2024  36 
17.  13005  PhD David Stopar  Plant production  Head  2021 - 2024  469 
18.  36800  Saša Terlep  Biochemistry and molecular biology  Researcher  2021 - 2024  12 
19.  57307  Marko Volk  Biochemistry and molecular biology  Researcher  2023 - 2024  4 
Organisations (4)
no. Code Research organisation City Registration number No. of publications
1.  0481  University of Ljubljana, Biotechnical Faculty  Ljubljana  1626914  66,322 
2.  0143  Fotona proizvodnja optoelektronskih naprav d.o.o. (Slovene)  Ljubljana  5045223000  895 
3.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,236 
4.  0782  University of Ljubljana, Faculty of Mechanical Engineering  Ljubljana  1627031  29,214 
Abstract
The incidences of biofilm related periodontal and peri-implant diseases are high. It is expected that on average one out of five patients with dental implants will suffer from severe peri-implant disease. The existent clinical, radiographic and microbiological data do not favor any decontamination approach and fail to show the influence of a particular decontamination protocol on surgical therapy. The limited effectiveness of current treatment methods is due to hard-to-reach biofilm sites in the periodontal and peri-implant space and toxicity of effective antimicrobial agents to vital dental and implant tissues. Recently, contact laser therapy has been proposed as a very promising new tool for non-surgical biofilm treatment, capable of removing up to 99.9 % of biofilm under in vitro conditions, but the direct contact laser therapy may cause local dental or implant tissue damage. Our current research results suggest that photoacoustic irrigation with Er:YAG lasers can achieve excellent biofilm cleaning results on titanium surfaces (Hympanova et al., 2020, Terlep et al., 2021) without severe side effects. Currently a major stumbling block for a wider application of photoacoustic therapy is poor understanding of hydrodynamic streaming in constricted geometries of periodontal and peri-implant space. In the proposed project we will apply new laser techniques and modalities developed in our laboratories to treat patients with severe periodontitis and peri-implantitis. To deliver this the project will be divided into three interrelated subprojects. First basic understanding of the effect of local geometry on photoacoustic, photodynamic, and photothermic induced hydrodynamic flow will be determined in manufactured 3D volumes that will mimic constricted geometries of periodontal and peri-implant space. Second, the optimized laser parameters in constrained geometries will be used to examine the biofilm removal efficiency in vitro in hard to reach biofilm sites. In the third subproject the best in vitro laser parameter setups for biofilm removal will be used to treat patients with stage III periodontitis and peri-implantitis in a large randomized controlled clinical study. One of the partners in the project team (Fotona d.o.o.) develops and produces optoelectronic devices in particular laser technology and equipment for the dedicated dental use. This will allow us to test flexible laser schemes and to use very efficient super short and ultrashort laser pulse technology to boost hydrodynamic streaming in constrained geometries of periodontal and peri-implant space. The proposed laser modalities proved to be very successful in endodontic tooth root canal biofilm removal, but have not been tested yet in periodontal and implant therapy. The photoacoustic streaming with different laser modalities will be combined with different irrigants, laser induced photodynamic, and photothermal therapy. The proposed line of research will fill the existing gap in our knowledge of the cavitation physics in constrained geometries and improve microbiological knowledge of the effect of cavitation on biofilms with a clear medical application target. Better understanding of cavitation phenomena is crucial to appreciate the potential of cavitation; where we are now and how far we can reach with the new technological advancements. It will also give dental practitioners a better feel for the technology they are using and the theoretical background for an improved therapy. We are aiming to introduce a new laser tool for the general dentist, specialists of periodontology, and oral surgery to treat periodontitis and peri-implantitis. These two diseases cause major dental related health problems worldwide. We expect that less invasive non-surgical laser treatments of periodontitis and peri-implantitis in comparison to advanced conventional surgical treatment might reduce the treatment burden substantially.
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