Projects / Programmes
Preprecevanje zozanja inervertebralnega prostora (Slovene)
| Code |
Science |
Field |
Subfield |
| 3.03.00 |
Medical sciences |
Neurobiology |
|
| Code |
Science |
Field |
| B600 |
Biomedical sciences |
Surgery, orthopaedics, traumatology |
| B210 |
Biomedical sciences |
Histology, cytochemistry, histochemistry, tissue culture |
elastic cartilage, nucleus pulposus, anulus fibrosus, spine, tissue engineering, biodegradable materials
Researchers (5)
Organisations (1)
Abstract
A surgical methods for treatment of defected intervertebral discus was established during last seventy years. After first successfull operations higher mobility of an operated segment was detected and patients were set in plaster. Later, hipermobility of the vertebral segments was prevented using spondylodesis. Different methods were developed for fixation of hypermobile segments using transpedicular screws and intervertebral metal intermediate pieces. This methods were were inappropriate as well because of higher mobility of nighbouring segments. Researchers and surgeons tried to construct artificial discus for prevention of narrowing of invertebral space. But migration of such implants into the bone of vertebral corpus was reported. Our goal is to develop a biological replacement of intervertebral disc which would prevent narrowing and stay alive. Chondrocytes isolated from rabbit''s ear will be cultivated and transferred to intervertebral space in lubmbal part of a rabbit''s spine. We will compare results of transplantation using autologous and allogenic chondrocytes and biodegradable implants containing cultivated chondrocytes.
