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Projects / Programmes source: ARIS

Reactive Intermediates in Oxidation Reactions

Periods
January 1, 1999 - December 31, 2003
Research activity

Code Science Field Subfield
1.04.00  Natural sciences and mathematics  Chemistry   

Code Science Field
P003  Natural sciences and mathematics  Chemistry 
P390  Natural sciences and mathematics  Organic chemistry 
P305  Natural sciences and mathematics  Environmental chemistry 
Evaluation (rules)
source: COBISS
Researchers (8)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  08385  PhD Janez Cerkovnik  Chemistry  Researcher  2001 - 2003  176 
2.  08337  PhD Darko Dolenc  Chemistry  Researcher  2001 - 2003  281 
3.  15905  PhD Evgen Eržen  Materials science and technology  Researcher  2001 - 2003  34 
4.  14517  PhD Berta Košmrlj  Chemistry  Researcher  2001 - 2003  98 
5.  06138  PhD Franci Kovač  Chemistry  Researcher  2001 - 2003  85 
6.  20458  Branka Miklavčič    Researcher  2001 - 2003 
7.  06137  PhD Božo Plesničar  Chemistry  Head  2001 - 2003  109 
8.  06061  PhD Boris Šket  Chemistry  Researcher  2001 - 2003  349 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0103  University of Ljubljana, Faculty of Chemistry and Chemical Technology  Ljubljana  1626990  23,294 
Abstract
Our long-term research goal is to provide new information on the synthesis, structure, and reactivity of a) alkyl hydrotrioxides (ROOOH), i.e., reactive intermediates formed in the low-temperature ozonation of various saturated organic substrates (hydrocarbons, alcohols, ethers, silanes, germanes), b) dialkyl trioxides (ROOOR), and c) hydrogen trioxide (HOOOH), which has been synthesized and characterized for the first time recently in our laboratory. We plan to continue our studies on iodanyl radicals (R-I-R), which are formed in the decomposition of various (alkylperoxy)- iodanes. The application of the desyl or 2-oxo-1,2-diphenylethyl moiety as a photolabile ligand for the release of phosphates, carboxylic acids, amino acids and nucleotides are becoming increasingly important research tools for introduction of reagents with precise spatial and temporal control. The synthesis and photochemical studies of fluoro substituted N- and O-desyl-caged versions of bioactive substances prepared from 2-chloro- (or bromo-) 2-fluoro-1-oxo-1,2-diphenyl- ethanes will be studied. Polycyclic aromatic hydrocarbons are widespread environmental pollutants. Benzo?a?pyrene can be metabolised into four isomers of diol epoxides, the (+)-(7R,8S)-diol-(9S,10R)epoxide predominates and has the most pronounced tumorigenicity. The vicinal hydroxy groups normally prefer the quasi-diequatorial orientation. Introduction of fluorine at position 6 of pyrene, which is peri to the benzylic hydroxyl, causes a conformational change of the angular tetrahydro ring and 6-fluoro analogue has no tumorigenic activity. Previously, two of the four possible isomeric diol epoxides of 6-fluorobenzo?a?pyrene were synthesized from the metabolically formed trans-(7R,8R)-dihydrodiol by known chemical methods. However, for structure-biology studies through DNA bonding, a convenient chemical synthesis that provides both the antipodes of the dihydrodiol and all from diol epoxides will be prepared.
Most important scientific results Final report
Most important socioeconomically and culturally relevant results Final report
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