Projects / Programmes
Intestinal transplantation
| Code |
Science |
Field |
Subfield |
| 3.06.00 |
Medical sciences |
Cardiovascular system |
|
| Code |
Science |
Field |
| B600 |
Biomedical sciences |
Surgery, orthopaedics, traumatology |
| B500 |
Biomedical sciences |
Immunology, serology, transplantation |
transplantation, small intestine, immunossuppression, bone marrow transplantation
Researchers (6)
Organisations (2)
Abstract
The research is based on the specific role of bone marrow transplantation for tolerance induction and maintaince after orthotopic small bowel transplantation.
We suppose that bone marrow transplantation can induce tolerance. Induction of tolerance is the basis for organ acceptance and maintaince after transplantation and to prolong small intestinal survilance after ortothopic small intestinal transplantation. Based on the protocol we use the minimal dose of immunossuppressant combination that can prevent high grade graft versus host disease. The substances used are specific to regulate the immune response in two different steps of immune sistem at the recipient.
In the protocol of research we intend to put out: the incidence of graft versus host disease, the incidence of infections and type of infections at the recipients after small intestinal transplantation, induction and maintenance of immunological tolarance, specific recipient skin graft versus host disease and its properties and modified technic of bone marrow cells isolation from donor vertebral bodies and femura.
At the protocol we are comparing two groups of experimental animals (pigs; white, big). The specific difference beetween two groups is based on bone marrow transplantation on day 3 posttransplant, after orthotopic small bowel transplantation. There are no other differences beetween two experimental groups.
