Loading...
Projects / Programmes source: ARIS

Intestinal transplantation

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B600  Biomedical sciences  Surgery, orthopaedics, traumatology 
B500  Biomedical sciences  Immunology, serology, transplantation 
Keywords
transplantation, small intestine, immunossuppression, bone marrow transplantation
Evaluation (rules)
source: COBISS
Researchers (6)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  03138  PhD Janoš Butinar  Oncology  Researcher  1998 - 1999  244 
2.  10395  PhD Aleksandra Domanjko Petrič  Veterinarian medicine  Researcher  1998 - 1999  262 
3.  16246  Diana Gvardijančič  Cardiovascular system  Researcher  1998 - 1999  71 
4.  07516  PhD Zlatko Pavlica  Veterinarian medicine  Researcher  1998 - 1999  376 
5.  10909  PhD Alojz Pleskovič  Neurobiology  Head  1999  197 
6.  17714  Anton Zorjan    Researcher  1998 - 1999 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,366 
2.  0406  University of Ljubljana, Veterinary Faculty  Ljubljana  1627139  10,756 
Abstract
The research is based on the specific role of bone marrow transplantation for tolerance induction and maintaince after orthotopic small bowel transplantation. We suppose that bone marrow transplantation can induce tolerance. Induction of tolerance is the basis for organ acceptance and maintaince after transplantation and to prolong small intestinal survilance after ortothopic small intestinal transplantation. Based on the protocol we use the minimal dose of immunossuppressant combination that can prevent high grade graft versus host disease. The substances used are specific to regulate the immune response in two different steps of immune sistem at the recipient. In the protocol of research we intend to put out: the incidence of graft versus host disease, the incidence of infections and type of infections at the recipients after small intestinal transplantation, induction and maintenance of immunological tolarance, specific recipient skin graft versus host disease and its properties and modified technic of bone marrow cells isolation from donor vertebral bodies and femura. At the protocol we are comparing two groups of experimental animals (pigs; white, big). The specific difference beetween two groups is based on bone marrow transplantation on day 3 posttransplant, after orthotopic small bowel transplantation. There are no other differences beetween two experimental groups.
Views history
Favourite