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Projects / Programmes source: ARIS

Genetic Toxicology and Cancer Biology

Periods
Research activity

Code Science Field Subfield
1.03.00  Natural sciences and mathematics  Biology   
1.05.00  Natural sciences and mathematics  Biochemistry and molecular biology   
3.04.00  Medical sciences  Oncology   

Code Science Field
P004  Natural sciences and mathematics  Biochemistry, Metabolism 
B002  Biomedical sciences  Biophysics 
B005  Biomedical sciences  Zoology 
B007  Biomedical sciences  Medicine (human and vertebrates) 
Evaluation (rules)
source: COBISS
Researchers (15)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  18466  PhD Aleš Bervar  Biochemistry and molecular biology  Researcher  2001 - 2003  26 
2.  02755  PhD Mihael Bricelj  Biology  Researcher  2003  226 
3.  18325  PhD Simon Caserman  Biochemistry and molecular biology  Researcher  2001 - 2003  108 
4.  19157  PhD Tanja Fatur  Public health (occupational safety)  Researcher  2001 - 2003  313 
5.  09892  PhD Metka Filipič  Biology  Researcher  2001 - 2003  587 
6.  07744  PhD Gorazd Kosi  Biology  Researcher  2003  359 
7.  07802  PhD Tamara Lah Turnšek  Biology  Head  2001 - 2003  1,023 
8.  17003  PhD Nataša Levičar  Biochemistry and molecular biology  Researcher  2001 - 2003  42 
9.  23609  PhD Janja Plazar  Educational studies  Researcher  2003  220 
10.  07736  PhD Bojan Sedmak  Biochemistry and molecular biology  Researcher  2003  232 
11.  16193  Nataša Sever  Pharmacy  Researcher  2001 - 2003  30 
12.  18348  Karmen Stanič    Researcher  2003  54 
13.  20766  PhD Miha Trinkaus  Neurobiology  Researcher  2001 - 2003  31 
14.  10974  PhD Irena Zajc  Biochemistry and molecular biology  Researcher  2001 - 2003  134 
15.  20767  PhD Bojana Žegura  Biology  Researcher  2001 - 2003  353 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0105  National Institute of Biology  Ljubljana  5055784  13,479 
Abstract
The programme is focused on two closely linked areas of research: (A) to determine the origin and mechanisms of damage to the genetic material (DNA) caused by environmental agents and to study ways of reversing it. (B) to establish biochemical changes occurring during the initiation, progression and spread of tumours, as a basis for developing diagnostic and prognostic markers and new therapeutic agents for preventing cancer. Add A) Environmental agents, including carcinogens, that can damage DNA are injurious to the health of humans, animals and plants. We are developing new methods, such as single cell electrophoresis, analysis of the interaction of agents with DNA, and induction of genetic instability, to study the mechanisms by which mutations occur. This is enabling us to study in parallel the mechanisms of anti-mutagenic agents from natural sources, which have potential use as anti-carcinogens. -These projects are coupled with relevant applied research, which includes monitoring genotoxic agents in the environment and epidemiological studies on populations exposed to environmental pollution. Add B.) Several genes are activated during the processes of carcinogenesis, and tumour progression leading to metastasis. Our research is focused on lysosomal proteinases, including cathepsins D, B and L, and their protein inhibitors (cystatins and stefins) in tumour cells. These proteinases play an important role in tumour cell invasion and the formation of new vessels in tumours. In order to study the molecular mechanisms of these processes and the biological factors, such as natural proteinase inhibitors, which may prevent tumorigenesis and metastasis, mostly of breast, lung and brain tumours, we are using and developing new in vitro invasion assays. This basic research is aimed at applications in the clinical field, chiefly the search for effective diagnostic and prognostic markers (in collaboration with the pharmaceutical company KRKA, d.d., Slovenia), and the development of new therapeutic agents for prevention of cancer and metastasis.
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Most important socioeconomically and culturally relevant results Final report
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