Projects / Programmes source: ARIS

Farmakologija - molekularna (Slovene)

January 1, 1999 - December 31, 2003
Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B740  Biomedical sciences  Pharmacological sciences, pharmacognosy, pharmacy, toxicology 
Evaluation (rules)
source: COBISS
Researchers (13)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  17934  Cvetka Blažek    Researcher  2001 - 2003 
2.  16341  MSc Orjeta Bonaca  Microbiology and immunology  Researcher  2001 - 2003  16 
3.  01169  PhD Marija Čarman-Kržan  Neurobiology  Head  2001 - 2003  170 
4.  08313  PhD Ilonka Ferjan  Neurobiology  Researcher  2001 - 2003  73 
5.  15169  PhD Damijana Mojca Jurič  Neurobiology  Researcher  2001 - 2003  103 
6.  17935  Jožica Košir    Researcher  2001 - 2003 
7.  08095  PhD Mojca Kržan  Neurobiology  Researcher  2001 - 2003  268 
8.  15536  PhD Metoda Lipnik Štangelj  Neurobiology  Researcher  2001 - 2003  206 
9.  17933  Tatjana Lovšin    Researcher  2001 - 2003 
10.  20344  PhD Špela Miklič  Pharmacy  Researcher  2001 - 2003  20 
11.  21386  PhD Mateja Štempelj  Biotechnology  Researcher  2001 - 2003  31 
12.  17941  Vesna Vidergar Ivanić    Researcher  2001 - 2003 
13.  17942  Katja Vodopivec Mohorčič    Researcher  2001 - 2003 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  45,335 
The research program deals with the molecular mechanisms involved in the synthesis, secretion and regulation of neurotrophic factors (NTF´s) in the neuronal and nonneuronal cells of CNS. In the peripheral system nerve growth factor (NGF), cytokins and some drugs, were used to elucidate their regulatory effect on histamine and 5-HT release from mast cells. Molecular characteristics of histamine and cytokine receptors involved in the CNS and PS were studied by radioligand binding technique. 1. Our specific interest involves pharmacological modulation of synthesis and secretion of NGF from neuronal and nonneuronal cells: Nerve growth factor is a trophic factor, which promotes development of sensory and sympathetic neurons, neuronal survival, induction of neurite outgrowth and synthesis of transmitter enzymes. Our recent studies showed that NGF synthesis and release could be modulated by several cytokins (IL-1beta, IL-6), neurotransmitters (histamine etc.) and other signaling molecules. They act through different molecular mechanisms, including activation of various receptors (IL-1, ?-adrenergic or histamine receptor) and various intracellular pathways. 2. Influence of cytokins, neurotrophic factors and drugs on histamine and serotonine release from rat peritoneal mast cells. NGF, GM-CSF, SCF, IL-3, IL-5 and some psychotropic substances (perazine, clozapine etc.) were shown to modulate histamine and 5-HT release from mast cells. 3. Histamine H1-¸ H2- and H3-receptors in the cardiovascular system and CNS. Our current studies include identification, characterization and comparison of molecular characteristics of central (nonneuronal cells) and peripheral (vascular tissue) histamine receptor subtypes. Newly synthesized histaminergic drugs (agonists) from the group of phenylhistamines and histaprodifens are studied on the above system to clarify their agonistic activity (in collaboration with the research group of dr. W. Schunack, Free University Berlin)
Most important scientific results Final report
Most important socioeconomically and culturally relevant results Final report
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