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Projects / Programmes source: ARIS

Role of cytomorphology, DNA measurements, Ki 67 and apoptosis for planning and predicting the effect of chemotherapy in thyroid cancer

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B200  Biomedical sciences  Cytology, oncology, cancerology 
B520  Biomedical sciences  General pathology, pathological anatomy 
Keywords
thyroid tumor, chemotherapy, DNA, Ki 67, apoptosis, FNAB
Evaluation (rules)
source: COBISS
Researchers (15)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  00705  PhD Marija Auersperg  Oncology  Researcher  2002 - 2004  203 
2.  10330  PhD Nikola Bešić  Oncology  Researcher  2002 - 2004  468 
3.  18298  PhD Erik Brecelj  Oncology  Researcher  2002 - 2004  207 
4.  02686  PhD Rastko Golouh  Oncology  Researcher  2002 - 2004  364 
5.  21759  PhD Milena Kerin Povšič  Oncology  Researcher  2002 - 2004  72 
6.  15076  PhD Veronika Kloboves-Prevodnik  Oncology  Researcher  2002 - 2004  290 
7.  04377  Tadeja Movrin-Stanovnik  Oncology  Researcher  2002 - 2003  31 
8.  04401  PhD Ana Pogačnik  Oncology  Head  2002 - 2004  168 
9.  12199  PhD Živa Pohar Marinšek  Oncology  Researcher  2002 - 2004  143 
10.  12230  Franc Pompe  Oncology  Researcher  2002 - 2004  44 
11.  08800  PhD Gregor Serša  Oncology  Researcher  2002 - 2004  1,516 
12.  19141  PhD Irena Srebotnik Kirbiš  Oncology  Researcher  2002 - 2004  92 
13.  14669  PhD Margareta Strojan Fležar  Oncology  Researcher  2002 - 2004  263 
14.  15829  MSc Radka Tomšič-Demšar  Oncology  Researcher  2002 - 2004  32 
15.  12198  Alenka Vodnik-Cerar  Oncology  Researcher  2002 - 2004  27 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,495 
Abstract
Anaplastic thyroid carcinoma is a fatal neoplasm with poor response to treatment. For improvements of local control and survival various combinations of chemotherapy (Cht) with radiation and surgery were used. In this study Cht with low dosed Vinblastine (VLB) and Adriamycin (Adria) will be combined with radiation. Locally advanced inoperable differentiated thyroid carcinoma is a therapeutic challenge. Infusions of low dosed VLB will be used for rapid reduction of tumors thus making possible surgical treatment. The effect of VLB and/or Adria will be studied in tumor models alone or in combination with radiation to further elucidate mechanisms of action including the effect of VLB on blood vessels. The role of cytomorphology, measurements of DNA, apoptosis and Ki 67 for the prediction of the Cht effect will be studied using Fine needle aspiration biopsy (FNAB) specimen of tumors and clinical data on the effect of Cht.
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