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Projects / Programmes source: ARIS

The role of serotonine in suicidal behavior

Research activity

Code Science Field Subfield
3.09.00  Medical sciences  Psychiatry   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B650  Biomedical sciences  Psychiatry, clinical psychology, psychosomatics 
B220  Biomedical sciences  Genetics, cytogenetics 
Keywords
suicide, serotonine, impulssivity, depression, aggression
Evaluation (rules)
source: COBISS
Researchers (7)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  05353  PhD Jožef Balažic  Public health (occupational safety)  Researcher  2002 - 2004  424 
2.  21039  PhD Mojca Gabrovšek  Biochemistry and molecular biology  Researcher  2002 - 2004 
3.  06135  PhD Radovan Komel  Biochemistry and molecular biology  Researcher  2002 - 2004  1,054 
4.  22125  Urša Mrevlje  Psychiatry  Researcher  2002 - 2004 
5.  05379  PhD Bojan Zalar  Medical sciences  Researcher  2002 - 2004  175 
6.  22072  PhD Tomaž Zupanc  Medical sciences  Researcher  2002 - 2004  191 
7.  02703  PhD Martina Žmuc Tomori  Psychiatry  Head  2002 - 2004  547 
Organisations (2)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,215 
2.  1620  University Psyhiatric Hospital  Ljubljana - Polje  1191004000  3,459 
Abstract
There are several factors in the etiology of suicidal behavior. Beside societal, cultural and psychosocial risk factors, some psychopathological phenomenons enhance the risk of suicide. The research has shown an outstanding association of suicidal behavior with depression,impulsive behavior and substance abuse. Especially first two features are linked to certain disturbance in serotonin neurotransmission, which are - at least partially - genetically determined. The impact of candidate genes has been most investigated in connection with serotonin (polymorphism gene TPH and TH). As a number of antidepressant drugs of new generation is focused to the function of serotonin neurotransmission, better understanding of these associations might help to prevent suicidal behavior by in-time therapeutic treatment of the subjects most at risk. The aim of the project is to identify some genetic factors in the serotonin neurotransmission in suicidal behavior. We will examine the human genome for genetic risk factors in 100 suicide victims and 100 control subjects matched by age and sex. The questionnaires assessing impulsivity and history of psychopathology will be applied.
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