Projects / Programmes
The role of serotonine in suicidal behavior
Code |
Science |
Field |
Subfield |
3.09.00 |
Medical sciences |
Psychiatry |
|
Code |
Science |
Field |
B007 |
Biomedical sciences |
Medicine (human and vertebrates) |
B650 |
Biomedical sciences |
Psychiatry, clinical psychology, psychosomatics |
B220 |
Biomedical sciences |
Genetics, cytogenetics |
suicide, serotonine, impulssivity, depression, aggression
Researchers (7)
no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
1. |
05353 |
PhD Jožef Balažic |
Public health (occupational safety) |
Researcher |
2002 - 2004 |
424 |
2. |
21039 |
PhD Mojca Gabrovšek |
Biochemistry and molecular biology |
Researcher |
2002 - 2004 |
8 |
3. |
06135 |
PhD Radovan Komel |
Biochemistry and molecular biology |
Researcher |
2002 - 2004 |
1,054 |
4. |
22125 |
Urša Mrevlje |
Psychiatry |
Researcher |
2002 - 2004 |
5 |
5. |
05379 |
PhD Bojan Zalar |
Medical sciences |
Researcher |
2002 - 2004 |
175 |
6. |
22072 |
PhD Tomaž Zupanc |
Medical sciences |
Researcher |
2002 - 2004 |
191 |
7. |
02703 |
PhD Martina Žmuc Tomori |
Psychiatry |
Head |
2002 - 2004 |
547 |
Organisations (2)
Abstract
There are several factors in the etiology of suicidal behavior. Beside societal, cultural and psychosocial risk factors, some psychopathological phenomenons enhance the risk of suicide. The research has shown an outstanding association of suicidal behavior with depression,impulsive behavior and substance abuse. Especially first two features are linked to certain disturbance in serotonin neurotransmission, which are - at least partially - genetically determined. The impact of candidate genes has been most investigated in connection with serotonin (polymorphism gene TPH and TH). As a number of antidepressant drugs of new generation is focused to the function of serotonin neurotransmission, better understanding of these associations might help to prevent suicidal behavior by in-time therapeutic treatment of the subjects most at risk.
The aim of the project is to identify some genetic factors in the serotonin neurotransmission in suicidal behavior. We will examine the human genome for genetic risk factors in 100 suicide victims and 100 control subjects matched by age and sex. The questionnaires assessing impulsivity and history of psychopathology will be applied.