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Projects / Programmes source: ARIS

Effects of modified external conditions on the shape of phospholipid vesicles

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Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B002  Biomedical sciences  Biophysics 
B120  Biomedical sciences  Molecular biophysics 
B130  Biomedical sciences  Physiological biophysics 
P340  Natural sciences and mathematics  Lipids, steroids, membranes 
Keywords
biological membrane, phospholipid vesicles
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publications
1.  11088  PhD Bojan Božič  Neurobiology  Head  2002 - 2004  119 
2.  18383  Dušan Dragaš    Researcher  2002 - 2004  0 
3.  18384  Marijan Kozamernik    Researcher  2002 - 2004  0 
4.  12001  PhD Janja Majhenc  Physics  Researcher  2003 - 2004  73 
5.  12531  PhD Primož Peterlin  Oncology  Researcher  2002 - 2004  133 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,236 
Abstract
Phospholipid bilayer is the basic constituent part of cell membranes. Phospholipids are amphiphilic molecules, which spontaneously form a bilayer in an aqueous medium. If the bilayer closes upon itself, a phospholipid vesicle is formed. The shape of flaccid vesicles and cells without internal structure depends on the elastic properties and environmental factors. We will theoretically describe the shape with derived equations, devised by a minimisation of thermodynamic potential. The response of vesicles and cells on modified environmental conditions will be observed with an optical microscope. We will try to investigate the conditions leading to transitions between different classes of shapes and to explain the dynamics of the process. The membrane properties will be studied via shape changes of closed phospholipid membranes depending on strength and frequency of applied electric field. Connecting the theoretical calculations with experiments, we will evaluate the nature of interactions between phospholipid membranes and environmental factors and determine the elastic properties of membranes.
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