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Projects / Programmes source: ARIS

Diagnostics and therapy of the nonpalpable breast cancer

Research activity

Code Science Field Subfield
3.04.00  Medical sciences  Oncology   

Code Science Field
B520  Biomedical sciences  General pathology, pathological anatomy 
B200  Biomedical sciences  Cytology, oncology, cancerology 
B145  Biomedical sciences  Nuclear medicine, radiobiology 
Keywords
nonpalpable breast cancer, radioguided occult lesion localisation, sentinel node
Evaluation (rules)
source: COBISS
Researchers (10)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  20817  Mojca Berlec  Computer science and informatics  Researcher  2002 - 2004 
2.  10330  PhD Nikola Bešić  Oncology  Researcher  2002 - 2004  474 
3.  14441  MSc Darja Eržen  Oncology  Researcher  2002 - 2004  82 
4.  21745  MSc Kristijana Hertl  Oncology  Researcher  2002 - 2004  182 
5.  12023  PhD Marko Hočevar  Oncology  Researcher  2002 - 2004  472 
6.  15830  Višnja Kolonić  Oncology  Researcher  2002 - 2004  12 
7.  15394  MSc Slavica Lahajnar  Oncology  Researcher  2002 - 2004  131 
8.  05278  PhD Jurij Lindtner  Oncology  Head  2002 - 2004  163 
9.  20175  Miljeva Rener  Oncology  Researcher  2002 - 2004  73 
10.  12767  PhD Janez Žgajnar  Oncology  Researcher  2002 - 2004  354 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0302  Institute of Oncology Ljubljana  Ljubljana  5055733000  15,789 
Abstract
The widespread use of mammografic screening has increased the detection of nonpalpable lesions. Suspicious nonpalpable breast lesions have to be diagnostically evaluated, if needed treated. During the process of diagnostics and therapy different procedures are performed; some of them (e.g.: Radioguided Occult Lesions Localization and sentinel node biopsy) still have to be evaluated. The aim of our study is the establishment of a modern diagnostic and therapeutic algorithm in management of the suspicious nonpalpable breast lesions. Such algorithm would be based not only on routine procedures already in use today but also on new methods; some of them transferred from other centers some of them original. The endpoints of our study are: 1. Introduction of the core biopsy of nonpalpable breast lesions as a standard procedure 2. Comparison of results of the fine needle aspiration (FNA), core biopsy and excisional biopsy 3. Introduction of ROLL to the Institute of Oncology 4. Comparison between ROLL and guidewire localization of nonpalpable breast lesions 5. Introduction of the sentinel node biopsy in nonpalpable breast cancer - development of the method of deep intraparenchimal injection of the radioisotope and the blue dye - development of the simultaneous ROLL and sentinel node biopsy Patients with mammograficaly or ultrasonicaly suspicious nonpalpable breast lesions will be enrolled in the study. Lesions will be first diagnosed by an FNA or core biopsy. If a cancer is confirmed, a surgical excision of the lesion will be performed using either method of localization (ROLL or wire guided). Simultaneously a sentinel node biopsy will be performed. In patients in whom cancer will not be confirmed by FNA or core biopsy, a diagnostic surgical excision will be performed. If cancer is confirmed the sentinel node biopsy will be performed in a separate procedure. Depending on the diagnosis patients will be additionally treated by adjuvant systemic treatment and/or radiotherapy according to the guidelines of the Institute of Oncology. Breast cancer patients will be followed up for at least five years.
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