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Projects / Programmes source: ARIS

Impact of ecotoxins on human health and quality of life

Research activity

Code Science Field Subfield
3.03.00  Medical sciences  Neurobiology   

Code Science Field
B007  Biomedical sciences  Medicine (human and vertebrates) 
B725  Biomedical sciences  Diagnostics 
B740  Biomedical sciences  Pharmacological sciences, pharmacognosy, pharmacy, toxicology 
B790  Biomedical sciences  Clinical genetics 
B720  Biomedical sciences  General practice, medical training 
Keywords
ecotoxins, diagnostics, detection, protein phosphatases, inhibition, MRI, MRS, comet assay, laser scanning confocal microscopy, carcinogenesis, tumor promotion, hepatotoxicity
Evaluation (rules)
source: COBISS
Researchers (9)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  13672  PhD Igor Bartenjev  Microbiology and immunology  Researcher  2002 - 2004  293 
2.  19722  PhD Tina Batista Napotnik  Systems and cybernetics  Researcher  2002 - 2004  61 
3.  15667  PhD Matjaž Bunc  Neurobiology  Researcher  2002 - 2004  531 
4.  16048  PhD Igor Fajdiga  Oncology  Head  2002 - 2004  113 
5.  21903  Alenka Frangež Štrukelj    Researcher  2002 - 2004 
6.  18549  PhD Aleksandra Milutinović Živin  Cardiovascular system  Researcher  2002 - 2004  126 
7.  08993  PhD Marko Potočnik  Public health (occupational safety)  Researcher  2002 - 2004  252 
8.  09861  Jerneja Strupi-Šuput  Civil engineering  Researcher  2002 - 2004  134 
9.  07002  PhD Dušan Šuput  Neurobiology  Researcher  2002 - 2004  436 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  48,743 
Abstract
Water eutrophication is a global problem also present in Slovenia. This facilitates the growth of blooms of microorganisms that may, and in fact they often do, produce potent toxins. Some of the toxins have already been detected in the water resources in Maribor. Therefore the health of population may be at a severe risk, especially when low doses of hepatotoxins are chronically present in food or water supplies. The proposed study will grant the development of procedures for the early detection of ecotoxins, and new insight into the mechanisms of acute and chronic toxicity. Microcystins are one of the most spread and harmful ecotoxins produced by cyanobacteria. These toxins lead to an acute liver failure with lethal intra hepatic haemorrhages. Recent reports have shown that acute intoxication with these substances is a real and serious threat to human population. Even more important is the chronics exposure of population to low doses of microcystins. These substances are powerful tumor promoters and carcinogens. Therfore it is not surprising that a legislation is being prepared in the EU, where the maximal allowable concentrations of microcystins will be set. It seems that the limit will be at the microcystins levels that cannot be detected with the presently available methods. The proposed project consists of the following specific aims: 1.) development and testing of an accurate and rapid assay for the detection of microcystins based on hepatocyte cultures in order to increase the sensitivity and replace animal testing 2.) to assess the risk of population due the chronic exposure in endangered areas 3.) to develop and apply simple and efficient diagnostic procedures to detect acute intoxication and to develop the diagnostic procedures for assessment the possible chronic effects of microcystins by means of MRI 4.) introduction and application of a rapid and accurate detection of genotoxicity of ecotoxins 5.) to prepare a publication with instructions and suggestions for the actions in the case of detection of microcystins in food or drinkable water supplies.
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