Projects / Programmes
Statin drug effect on carotid and coronary artery disease
| Code |
Science |
Field |
Subfield |
| 3.06.00 |
Medical sciences |
Cardiovascular system |
|
| Code |
Science |
Field |
| B640 |
Biomedical sciences |
Neurology, neuropsychology, neurophysiology |
Atherosclerosis, Carotid disease, Coronary disease, Statins
Researchers (5)
Organisations (1)
Abstract
Background: Atherosclerosis is a generalized pathological process with clinical manifestation in accordance to the region affected. Various studies demonstrated correlation between carotid and coronary disease. How closely quantitative and qualitative atherosclerotic changes of carotids relate to those on coronaries and whether they have any prognostic value remains to be examined. The effect of high dose statin treatment on carotid and coronary atherosclerosis is not yet fully understood. The question whether the effect on quality and quantity of atherosclerosis is simultaneous and generalized remains to be answered in order to improve the knowledge of these drugs. Patients treated with the certain dose of statins will undergo the 3-years of follow-up and potential clinical improvement and reduced need for revascularisation interventions will be noted.
Methods and plan of the study: Two patient groups in the age range of 30-70 years will be subjected to certain dose of statin treatment in order to achieve significant fall in plasma LDL. Other treatment regimen will not be changed. Carotid and coronary disease risk factors will be evaluated. They will be followed up by ultrasound carotid and lipidogram examination every trimester and twice per year with stress test and echocardiography. When indicated, coronary angiography will be performed and direct coronary affection demonstrated.
