Projects / Programmes source: ARIS

Statin drug effect on carotid and coronary artery disease

Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B640  Biomedical sciences  Neurology, neuropsychology, neurophysiology 
Atherosclerosis, Carotid disease, Coronary disease, Statins
Evaluation (rules)
source: COBISS
Researchers (5)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  18480  Valentin Beznik    Researcher  2002 - 2004 
2.  01978  PhD Miran Frančišek Kenda  Cardiovascular system  Researcher  2002 - 2004  173 
3.  08094  PhD Mirza Šabovič  Cardiovascular system  Researcher  2002 - 2004  412 
4.  11647  PhD Marjan Zaletel  Neurobiology  Researcher  2002 - 2004  711 
5.  05352  PhD Bojana Žvan  Neurobiology  Head  2002 - 2004  786 
Organisations (1)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  74,805 
Background: Atherosclerosis is a generalized pathological process with clinical manifestation in accordance to the region affected. Various studies demonstrated correlation between carotid and coronary disease. How closely quantitative and qualitative atherosclerotic changes of carotids relate to those on coronaries and whether they have any prognostic value remains to be examined. The effect of high dose statin treatment on carotid and coronary atherosclerosis is not yet fully understood. The question whether the effect on quality and quantity of atherosclerosis is simultaneous and generalized remains to be answered in order to improve the knowledge of these drugs. Patients treated with the certain dose of statins will undergo the 3-years of follow-up and potential clinical improvement and reduced need for revascularisation interventions will be noted. Methods and plan of the study: Two patient groups in the age range of 30-70 years will be subjected to certain dose of statin treatment in order to achieve significant fall in plasma LDL. Other treatment regimen will not be changed. Carotid and coronary disease risk factors will be evaluated. They will be followed up by ultrasound carotid and lipidogram examination every trimester and twice per year with stress test and echocardiography. When indicated, coronary angiography will be performed and direct coronary affection demonstrated.
Views history