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Projects / Programmes source: ARIS

Ecological and epidemiological characteristics of ehrlichiae in Slovenia

Research activity

Code Science Field Subfield
3.01.00  Medical sciences  Microbiology and immunology   

Code Science Field
B230  Biomedical sciences  Microbiology, bacteriology, virology, mycology 
Keywords
tick-borne diseases, ehrlichiae, ecology, epidemiology, vectors, natural reservoirs, Slovenia
Evaluation (rules)
source: COBISS
Researchers (7)
no. Code Name and surname Research area Role Period No. of publicationsNo. of publications
1.  16235  PhD Maja Arnež  Microbiology and immunology  Researcher  2002 - 2004  184 
2.  10331  PhD Tatjana Avšič-Županc  Microbiology and immunology  Researcher  2002 - 2004  808 
3.  21334  PhD Darja Duh  Medical sciences  Researcher  2002 - 2004  149 
4.  13299  PhD Stanka Lotrič Furlan  Microbiology and immunology  Researcher  2002 - 2004  335 
5.  15902  PhD Miroslav Petrovec  Microbiology and immunology  Head  2002 - 2004  450 
6.  13301  PhD Franc Strle  Microbiology and immunology  Researcher  2002 - 2004  849 
7.  10061  PhD Tomi Trilar  Biology  Researcher  2002 - 2004  1,016 
Organisations (3)
no. Code Research organisation City Registration number No. of publicationsNo. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  78,437 
2.  0381  University of Ljubljana, Faculty of Medicine  Ljubljana  1627066  49,116 
3.  0614  Slovenian Museum of Natural History  Ljubljana  5052670000  5,951 
Abstract
Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne disease in the United States. Serologic evidence of human infection has been reported from several European countries. The first European case of acute HGE was confirmed in Slovenia in 1996. It appears likely that tick I. ricinus is a vector of the HGE agent in Europe. In Slovenia, as in other European countries, I. ricinus is also the main vector of the causative agents of Lyme borreliosis and tick-borne encephalitis. This study will document the incidence and importance of HGE to other tick transmitted infections in Slovenia, where all three pathogens are endemic. A clinically based prospective study will be conducted to enroll patients who will donate blood. An attempt to isolate and characterize the agent causing ehrlichiosis in Slovenia will be done. In the USA, white-tailed deer and small mammals may serve as primary reservoirs of the HGE agent, and the tick, Ixodes scapularis, has been shown to be a competent vector. Therefore, ticks, small mammals and deer material will be collected from the endemic regions and subsequently examined for the presence of the HGE agent by using serological and molecular techniques. Antigenic and genetic characterization of the isolate(s) or DNA by PCR and sequencing of multiple genes will be performed. Results of the comparative analysis between the HGE agent recovered from humans and those found in reservoir and vector species will benefits to a better understanding of the epizootiology of ehrlichial infections.
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