Projects / Programmes
Ecological and epidemiological characteristics of ehrlichiae in Slovenia
Code |
Science |
Field |
Subfield |
3.01.00 |
Medical sciences |
Microbiology and immunology |
|
Code |
Science |
Field |
B230 |
Biomedical sciences |
Microbiology, bacteriology, virology, mycology |
tick-borne diseases, ehrlichiae, ecology, epidemiology, vectors, natural reservoirs, Slovenia
Researchers (7)
no. |
Code |
Name and surname |
Research area |
Role |
Period |
No. of publicationsNo. of publications |
1. |
16235 |
PhD Maja Arnež |
Microbiology and immunology |
Researcher |
2002 - 2004 |
184 |
2. |
10331 |
PhD Tatjana Avšič-Županc |
Microbiology and immunology |
Researcher |
2002 - 2004 |
808 |
3. |
21334 |
PhD Darja Duh |
Medical sciences |
Researcher |
2002 - 2004 |
149 |
4. |
13299 |
PhD Stanka Lotrič Furlan |
Microbiology and immunology |
Researcher |
2002 - 2004 |
335 |
5. |
15902 |
PhD Miroslav Petrovec |
Microbiology and immunology |
Head |
2002 - 2004 |
450 |
6. |
13301 |
PhD Franc Strle |
Microbiology and immunology |
Researcher |
2002 - 2004 |
849 |
7. |
10061 |
PhD Tomi Trilar |
Biology |
Researcher |
2002 - 2004 |
1,016 |
Organisations (3)
Abstract
Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne disease in the United States. Serologic evidence of human infection has been reported from several European countries. The first European case of acute HGE was confirmed in Slovenia in 1996. It appears likely that tick I. ricinus is a vector of the HGE agent in Europe. In Slovenia, as in other European countries, I. ricinus is also the main vector of the causative agents of Lyme borreliosis and tick-borne encephalitis. This study will document the incidence and importance of HGE to other tick transmitted infections in Slovenia, where all three pathogens are endemic. A clinically based prospective study will be conducted to enroll patients who will donate blood. An attempt to isolate and characterize the agent causing ehrlichiosis in Slovenia will be done. In the USA, white-tailed deer and small mammals may serve as primary reservoirs of the HGE agent, and the tick, Ixodes scapularis, has been shown to be a competent vector. Therefore, ticks, small mammals and deer material will be collected from the endemic regions and subsequently examined for the presence of the HGE agent by using serological and molecular techniques. Antigenic and genetic characterization of the isolate(s) or DNA by PCR and sequencing of multiple genes will be performed. Results of the comparative analysis between the HGE agent recovered from humans and those found in reservoir and vector species will benefits to a better understanding of the epizootiology of ehrlichial infections.