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Projects / Programmes source: ARIS

Contribution of ECG gating to the value of myocardial perfision scintigraphy in the assessment of ischaemic heart disease

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Research activity

Code Science Field Subfield
3.06.00  Medical sciences  Cardiovascular system   

Code Science Field
B145  Biomedical sciences  Nuclear medicine, radiobiology 
B530  Biomedical sciences  Cardiovascular system 
Keywords
Perfusion myocardial scintigraphy, ECG gating, quality assurance, artificial inteligence
Evaluation (rules)
source: COBISS
Evaluation of bibliographic research performance indicators according to ARIS methodology
Citations Citations for bibliographic records in COBIB.SI that are linked to records in citation databases
source: WoS source: Scopus source: COBISS
Researchers (8)
no. Code Name and surname Research area Role Period No. of publications
1.  09790  PhD Jurij Fettich  Cardiovascular system  Head  2002 - 2004  297 
2.  09791  PhD Valentin Fidler  Cardiovascular system  Researcher  2002 - 2004  118 
3.  15706  PhD Tanja Gmeiner  Pharmacy  Researcher  2002 - 2004  147 
4.  06769  PhD Ciril Grošelj  Cardiovascular system  Researcher  2002 - 2004  85 
5.  16192  MSc Tomaž Milanez  Oncology  Researcher  2002 - 2004  70 
6.  09070  PhD Metka Milčinski  Cardiovascular system  Researcher  2002 - 2004  140 
7.  05366  Milan Prepadnik  Cardiovascular system  Researcher  2002 - 2004  51 
8.  17683  Ivan Slodnjak    Researcher  2002 - 2004  42 
Organisations (1)
no. Code Research organisation City Registration number No. of publications
1.  0312  University Medical Centre Ljubljana  Ljubljana  5057272000  77,422 
Abstract
Stress perfusion myocardial tomographic scintigraphy using 99m-Tc MIBI has highest specificity (78%) and sensitivity (88%) among noninvasive diagnostic methods to diagnose ischaemic heart disease (IHD). Using ECG gated myocardial perfusion tomography (Gated SPECT) one can obtain in addition to information on myocardial perfusion also information on global (left ventricular ejection fraction - LVEF) and regional (regional contractility and thickening of left ventricular walls) left ventricular function. This additional information can be used to increase specificity of this investigation to detect IHD, by avoiding false positive results. Especially in patients where false positive results are frequent (attenuation artefacts due to obesity, breast tissue or due to left bundle branch block etc.) speciticity can be increased to 92%. The aim of the investigation is to evaluate additional parameters (LVEF, regional contractility and thickening - independently and in combinations) and their importance by 1) assesing quality of software programs comparing results to independent diagnostic methods such as echocardiography, ventriculography, and coronarography), 2) evaluating additional diagnostic value of these parameter using artificial inteligence methods (neural networks), and 3) determining overall additional accuracy of gated myocardial SPECT to diagnose IHD as compared with usual myocardial perfusion tomography.
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