Projects / Programmes
Contribution of ECG gating to the value of myocardial perfision scintigraphy in the assessment of ischaemic heart disease
Code |
Science |
Field |
Subfield |
3.06.00 |
Medical sciences |
Cardiovascular system |
|
Code |
Science |
Field |
B145 |
Biomedical sciences |
Nuclear medicine, radiobiology |
B530 |
Biomedical sciences |
Cardiovascular system |
Perfusion myocardial scintigraphy, ECG gating, quality assurance, artificial inteligence
Researchers (8)
Organisations (1)
Abstract
Stress perfusion myocardial tomographic scintigraphy using 99m-Tc MIBI has highest specificity (78%) and sensitivity (88%) among noninvasive diagnostic methods to diagnose ischaemic heart disease (IHD). Using ECG gated myocardial perfusion tomography (Gated SPECT) one can obtain in addition to information on myocardial perfusion also information on global (left ventricular ejection fraction - LVEF) and regional (regional contractility and thickening of left ventricular walls) left ventricular function. This additional information can be used to increase specificity of this investigation to detect IHD, by avoiding false positive results. Especially in patients where false positive results are frequent (attenuation artefacts due to obesity, breast tissue or due to left bundle branch block etc.) speciticity can be increased to 92%.
The aim of the investigation is to evaluate additional parameters (LVEF, regional contractility and thickening - independently and in combinations) and their importance by
1) assesing quality of software programs comparing results to independent diagnostic methods such as echocardiography, ventriculography, and coronarography),
2) evaluating additional diagnostic value of these parameter using artificial inteligence methods (neural networks), and
3) determining overall additional accuracy of gated myocardial SPECT to diagnose IHD as compared with usual myocardial perfusion tomography.